Ending Iran’s Regime: Prospects & Challenges | The Cipher Brief
- As Israel's bombing campaign intensifies, the long-simmering conflict with Iran takes on new dimensions.
- Netanyahu recently urged the Iranian people to "unite around its flag and its historic legacy by standing up for your freedom from the evil and oppressive regime."
- Reactions within Iran are complex, marked by both defiance and division.
iran’s Future: Examining the U.S. Role in Potential Regime Change
Updated June 21, 2025
As Israel’s bombing campaign intensifies, the long-simmering conflict with Iran takes on new dimensions. While Israeli Foreign Minister Gideon Sa’ar maintains that regime change in Tehran is not the official goal, Prime Minister Benjamin Netanyahu appears to be signaling support for an internal uprising.
Netanyahu recently urged the Iranian people to “unite around its flag and its historic legacy by standing up for your freedom from the evil and oppressive regime.”
Reactions within Iran are complex, marked by both defiance and division. History shows that dissent in Iran has been met with brutal crackdowns, making a accomplished uprising a daunting prospect.
Reza khanzadeh, Senior Foreign Policy Advisor to the U.S.-Iran Chamber of Commerce, believes a “perfect storm” is needed for the Islamic republic to fall. This includes widespread weakening of power structures, important defection from military members, a massive national uprising, and a strong opposition leader.
Past anti-government protests, such as the Green Movement of 2009 and the demonstrations of 2017 and 2019, were violently suppressed.Karl Kaltenthaler, professor of political science at the University of Akron, said the regime’s unbroken chain of command and loyal security forces are key to its survival. He added that the Islamic Revolutionary Guard Corps (IRGC) is intent on preserving the regime.
John Thomas,Managing Director of Nestpoint Associates,argues that crippling Iran’s oil revenue and banking access through sanctions is crucial to igniting internal collapse. He said reform is unlikely while the IRGC remains strong, and overthrow requires splitting their ranks.
Janatan Sayeh, a research analyst at the Foundation for Defense of Democracies, suggests that Israel could have messaged directly to Iranians, offering support for their fight for freedom. He also criticized the current messaging, saying Washington is telling Iranians to evacuate Tehran while concurrently bombing.
Amid increasing pressure, the U.S. State Department recently recalled staffers to revive Voice of America’s Farsi-language broadcasts.
Khanzadeh warns that U.S. involvement should be restrained, advocating for a light-handed approach even if the conditions for regime change are present.
Analysts point to economic hardships, intensified Israeli strikes, and a younger population more connected to global ideas as factors contributing to potential instability. Though, the leadership’s resilience and control over internal security remain significant obstacles.
Kaltenthaler observes that even the death of the Supreme Leader would not necessarily lead to regime collapse,as there is no organized opposition strong enough to topple the IRGC-clerical regime.
Khanzadeh notes that the likelihood of a sustained opposition or regime change is very low, citing Iran’s high brain drain and the jaded attitude of its citizens.
What’s next
despite the challenges, some Iranians remain optimistic. The coming months will reveal whether internal pressures and external actions can create the conditions for significant change in Iran.
