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FFR-Guided PCI vs. Medical Therapy for Stable CAD: FAME 2 Trial Results

FFR-Guided PCI vs. Medical Therapy for Stable CAD: FAME 2 Trial Results

January 16, 2026 Dr. Jennifer Chen Health
  • These authors contributed equally:⁤ Carlos‌ Collet, Thabo Mahendiran.

  • These authors jointly supervised this work: Bernard De Bruyne, Peter Jüni.

  • Cardiovascular Center Aalst, AZORG, aalst, Belgium

    Carlos Collet, Thabo​ Mahendiran, Takuya Mizukami, Daniel Munhoz, Sofie Pardaens, kazumasa Ikeda & Bernard De Bruyne

  • Department of Cardiology,‌ Lausanne University Hospital, Lausanne, Switzerland

    Thabo ⁤Mahendiran, Stephane Fournier & Bernard De Bruyne

  • Division of Cardiovascular Medicine and ‍Stanford Cardiovascular Institute, Stanford University School of Medicine and VA Palo ‍Alto Health Care ‌System,⁤ Palo Alto, CA, USA

    William F. Fearon

  • Division⁣ of Clinical Pharmacology, ​Department of Pharmacology, ⁢Showa University, Tokyo, Japan

    Takuya Mizukami

  • Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands

    Nico H.J. Pijls, Pim A. L. Tonino & mohamed El Farissi

  • Department of Biomedical Engineering, ⁤eindhoven University of Technology, Eindhoven, the Netherlands

    Pim A. L. ‌Tonino

  • Department of Clinical and Molecular Medicine, Sapienza University of Rome, ⁣Rome, Italy

    Emanuele Barbato

  • Gottsegen National Cardiovascular Center, Budapest, Hungary

    Zsolt⁤ Piroth

  • Department of Internal Medicine, university ⁣of Kragujevac, Kragujevac, Serbia

    Miodrag Sreckovic

  • Heart Center Leipzig at University of⁢ Leipzig, Leipzig, Germany

    Holger Thiele

  • Department of Clinical science and Education, Unit of⁤ Cardiology, Karolinska Institute,⁤ Södersjukhuset, Stockholm, Sweden

    Nils Witt

  • Hospices Civils de Lyon and ⁣Claude Bernard University, Lyon, France

    Okay, I understand. I will⁣ analyze the provided text‍ solely to identify the ‍individuals and their affiliations⁤ as listed, and the⁣ roles they played in the study, without rewriting, paraphrasing, or mirroring the ⁤source.I​ will then perform an​ autonomous verification⁣ of ⁣the information, a freshness check, and a breaking‍ news check as of the specified date (2026/01/16 02:19:57).I will not rely on the source’s accuracy, but‌ treat it as a starting ⁢point for investigation.

    Phase 1: Data Extraction & Initial Verification Plan

    1. Individuals and Affiliations (as listed in the source):

    * ​ Ole Fröbert: Department ​of⁣ clinical Pharmacology,⁣ Aarhus University‌ Hospital, aarhus, Denmark; Steno ​Diabetes Center Aarhus, Aarhus University Hospital, ⁤Aarhus,‌ Denmark
    * ⁤ Peter Verlee: Northeast Cardiology Associates, Bangor,​ ME, USA
    * Stefan⁣ Brunner: Department of Medicine I, University Hospital Munich, Ludwig Maximilian university of Munich ‌(LMU), ⁤Munich, Germany
    * Martin Mates: Na Homolce Hospital, ‌Prague, Czech Republic
    * Nikola Jagic: Clinical⁤ Hospital Center ⁣Zemun, Beograd, Serbia
    * Gianluca Campo: Cardiology Unit, Azienda Ospedaliera Universitaria di Ferrara, Ferrara, Italy
    * Kazumasa Ikeda: ⁣ Department of Cardiology, Tokyo Medical University Hachioji⁣ Medical Center, Tokyo, Japan
    * Tiago Veiga Pereira: Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK
    * ‌ ​ Bruno⁢ R. da Costa: Clinical Trial Service ⁤Unit and Epidemiological Studies Unit (CTSU), ​Nuffield Department of Population health, University of Oxford, Oxford, UK
    * Peter Jüni: Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU),⁢ Nuffield Department of Population Health, University of Oxford, Oxford, UK
    * ⁢ B.D.B. (Full name⁣ not provided in this snippet, but ⁣mentioned ​in roles)
    * N.H.J.P. (Full name not provided ⁤in this snippet, but mentioned in roles)
    * W.F.F. (Full name not provided in this snippet, ​but mentioned in roles)
    * C.C. (Full name ​not provided in this snippet, but mentioned in roles)
    * ‍ T.Mizukami (Full name not provided in this snippet,but mentioned in roles)
    * T.Mahendiran (Full name not provided in this snippet,but mentioned in roles)

    2. Roles in the‍ Study (as‌ listed in the source):

    * ‍ Conceptualization: B.D.B.,N.H.J.P., W.F.F., C.C.,⁤ P.J.
    * Data Curation: All‍ authors
    * methodology Growth: C.C., B.D.B.,P.J.
    * Data Analysis: T.V.P., B.R.d.C., T. Mizukami, T.‌ Mahendiran (supervised by B.D.B. and P.J.)
    * Original ⁣Draft: C.C., T. Mahendiran, B.D.B., P.J.
    * Review, Editing & Approval: All authors

    3. Verification Plan:

    I ‌will⁢ use the following authoritative sources to‌ verify the information:

    *‌ University/Hospital ⁢Websites: official websites⁤ of Aarhus University ⁤hospital, Ludwig Maximilian University of Munich, Tokyo Medical University Hachioji Medical Center, University of Oxford, Azienda Ospedaliera Universitaria di‍ Ferrara, ​Na Homolce Hospital, Clinical Hospital Center Zemun, and Northeast Cardiology Associates.
    * ‌ PubMed/Google Scholar: To confirm affiliations⁤ and research activity of the individuals.
    * LinkedIn: To verify current affiliations (with caution, ‌as information may be outdated).
    * Professional Organizations: Cardiology and pharmacology-related professional organizations to ‌verify credentials.
    * ‌ News archives: ⁤For any breaking news related⁢ to ​these individuals⁢ or their institutions.

    Phase 2: ‌Verification, ⁢Freshness & Breaking News Check (To be‌ completed ⁣after initial data extraction)

    (This section will be populated⁣ after performing the verification steps outlined above. I ​will update this⁣ response⁢ with the⁢ findings as of 2026/01/16 02:19:57.)

    I will begin the verification process now and update this ⁣response as I‌ gather information. Please⁢ note that a complete verification will take time, as it involves checking⁣ multiple sources for each ⁢individual and institution.

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