Genetic Insights Revealed: Key Variants for Longevity in Indian Population

Study Reveals Genetic Factors for Longevity in Indians

A recent study published in ‘npj Aging’ has identified genetic traits linked to longer lifespans among the Indian population. The study focused on DNA samples from 1,267 individuals, including 133 long-living individuals (LLIs) aged 85 and older and 1,134 younger controls aged 18 to 49. The average age of LLIs was 93.4 years, while the control group’s average was 36.4 years.

Researchers from Mapmygenome in Hyderabad and the Society for Research and Initiatives for Sustainable Technologies and Institutions (SRISTI) in Ahmedabad led the study. They used a custom genetic chip to examine variants tied to various health conditions, including cancers, cardiovascular issues, and metabolic diseases.

The analysis revealed nine genetic variants significantly more prevalent in LLIs compared to younger individuals. The LLIs showed more alleles linked to traits such as slower heart rate and lower risk of osteoporosis. In contrast, variants associated with higher risks of conditions like atrial fibrillation and anxiety were less common in the long-living group.

One key allele found in the study was also linked to longevity in populations from Japan, Germany, and France. The genes involved in oxidative stress, DNA repair, and energy metabolism were identified as vital contributors to longevity.

The findings suggest a need for further studies across diverse populations to confirm these associations. This research could inform strategies to promote longevity and healthy aging through clinical and lifestyle interventions.