Global Head and Neck Cancer Trends 1990-2021: Global Burden of Disease Study
- Here's a breakdown of the key findings regarding the global burden and trends of Oral and pharyngeal Cancer (OPC) and Laryngeal Cancer (LC), based on the provided text:
- * Incidence: OPC incidence was absent in those under 20-24 years old, peaking in the 60-64 age group in 2021 (Fig.
- * Incidence: Global LC incidence increased by 60.48% (95% UI, 48.46%−74.30%) since 1990, reaching 200,800 cases in 2021.
Summary of Oral and Pharyngeal Cancer (OPC) and Laryngeal Cancer (LC) Global Burden (2021 Data & Trends 1990-2021)
Here’s a breakdown of the key findings regarding the global burden and trends of Oral and pharyngeal Cancer (OPC) and Laryngeal Cancer (LC), based on the provided text:
Oral and Pharyngeal Cancer (OPC):
* Incidence: OPC incidence was absent in those under 20-24 years old, peaking in the 60-64 age group in 2021 (Fig. 4D).
* Mortality: OPC deaths initially increased but declined after the 60-64 age group in 2021 (Fig. 5D).
* Further Data: Prevalence and Disability-Adjusted Life Years (DALYs) data are available in supplementary materials (Tables S4-5, Figures S5-8).
Laryngeal Cancer (LC):
* Incidence: Global LC incidence increased by 60.48% (95% UI, 48.46%−74.30%) since 1990, reaching 200,800 cases in 2021.
* Mortality: Global LC mortality increased by 36.67% (95% UI, 24.52%−48.70%) compared to 2019, with 117,250 deaths in 2021.
* ASIR (Age-Standardized Incidence Rate): 2.29 (95% UI, 2.13-2.47) per 100,000 in 2021, a 25.34% decline as 1990.
* ASMR (Age-Standardized Mortality Rate): 1.35 (95% UI, 1.26-1.45) per 100,000 in 2021, a 37.09% decrease since 1990.
* EAPC (Estimated Annual Percentage Change): -1.09 (95% UI: -1.16, -1.01) for ASIR and -1.39 (95% UI: -1.48, -1.30) for ASMR from 1990-2021.
* Overall Trend: Crude ASIR, ASPR, ASDR, and ASMR showed a stable trend from 1990 to 2021.
* Regional Variation (2021):
* Highest ASIR: Central Europe [4.46 (95% UI, 4.07-4.87) per 100,000]
* Lowest ASIR: Oceania [0.56 (95% UI, 0.44-0.74) per 100,000]
* Highest ASMR: caribbean [2.69 (95% UI, 2.33-3.13) per 100,000]
* Lowest ASMR: High-income Asia Pacific [0.31 (95% UI, 0.27-0.35) per 100,000]
* National Variation (2021):
* Highest ASIR: Monaco [10.44 (95% UI, 7.80-14.22) per 100,000]
* Lowest ASIR: Kiribati [0.23 (95% UI, 0.16-0.32) per 100,000]
* Lowest Mortality: Kiribati (further details incomplete in the provided text).
Note: The text frequently references supplementary materials (Tables S1-S5, Figures S2-S8) for more detailed data.