Immune Loop Inflammation Aging Research
- The Atherosclerosis Risk in Communities (ARIC) study, a long-term research project investigating the causes and progression of atherosclerosis, receives substantial funding from the National Heart, Lung, and Blood...
- The ARIC study is a prospective epidemiological study designed to identify risk factors for atherosclerosis, heart disease, and stroke.
- Example: As of 2023, ARIC data has contributed to over 1,000 peer-reviewed publications, influencing clinical guidelines and public health recommendations related to cardiovascular disease prevention.
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The Atherosclerosis Risk in Communities (ARIC) study, a long-term research project investigating the causes and progression of atherosclerosis, receives substantial funding from the National Heart, Lung, and Blood Institute (NHLBI) and collaborates with private companies like SomaLogic Inc. for specialized analyses.
Atherosclerosis Risk in Communities (ARIC) Study
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The ARIC study is a prospective epidemiological study designed to identify risk factors for atherosclerosis, heart disease, and stroke. It began in 1985 and has followed a cohort of over 15,000 adults aged 35-64 from four U.S. communities: Forsyth County,North Carolina; Jackson,Mississippi; minneapolis,Minnesota; and Washington County,Maryland. The NHLBI continues to oversee and fund the study.
Example: As of 2023, ARIC data has contributed to over 1,000 peer-reviewed publications, influencing clinical guidelines and public health recommendations related to cardiovascular disease prevention.
National Heart, Lung, and Blood Institute (NHLBI) Funding
The NHLBI, a component of the National Institutes of Health (NIH), provides the primary funding for the ARIC study. Contract numbers 75N92022D00001 through 75N92022D00005 represent recent funding allocations for the study.
detail: The NHLBI’s mission is to provide leadership and support for research to prevent and treat heart, lung, blood, and sleep disorders. Funding for ARIC aligns with this mission by supporting research into the underlying causes of cardiovascular disease.
Evidence: The current funding contracts, as stated in the source, are active as of the provided text’s origin, and NIH grant programs are publicly searchable.
SomaLogic inc. Collaboration
SomaLogic Inc. performed SomaScan assays on ARIC study samples in exchange for access to the ARIC data. SomaScan is a proteomic technology that allows for the measurement of thousands of proteins simultaneously.
Detail: This collaboration allows researchers to explore the proteomic landscape of cardiovascular disease risk factors, perhaps identifying novel biomarkers and therapeutic targets. The exchange of services for data is a common practise in large-scale research projects.
Example: In 2022, researchers used SomaScan data from ARIC to identify novel protein signatures associated with incident heart failure. SomaLogic’s website details applications of their technology in cardiovascular research.
Additional NIH Grant Support (R01 HL134320)
The work described is also partially supported by NIH/NHLBI grant R01 HL134320. This grant provides additional funding for specific aspects of the research.
Detail: R01 grants are research project grants, a common funding mechanism used by the NIH to support investigator-initiated research.