Long COVID Risk in Children: Twice as High After Second Infection

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Key Findings:

* Reinfection increases risk: Children and adolescents who experience COVID-19 reinfection are at a higher risk of developing long COVID,even with vaccination.
* Serious conditions linked to reinfection: Reinfection was associated with rare but possibly serious conditions like myocarditis (heart inflammation), blood clots, kidney injury, cognitive difficulties, fatigue, and respiratory problems.
* Vaccination remains crucial: While not eliminating risk entirely,vaccines and preventative measures (masking,social distancing) are still the most effective way to prevent initial infections and reinfections,thus lowering the chance of long COVID symptoms.
* Need for increased vaccination: The study highlights the importance of boosting COVID-19 vaccination rates in children and adolescents.

Study details:

* Published in: The lancet Infectious Diseases (2025)
* type: Retrospective cohort study (RECOVER-EHR)
* DOI: 10.1016/S1473-3099(25)00476-1