Master Regulators: Therapeutic Vulnerabilities Explained
- KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2.Nature Communications.
- * Provided by: Cold Spring Harbor Laboratory (https://medicalxpress.com/partners/cold-spring-harbor-laboratory/, http://www.cshl.edu/index.html)
- * Title: Shapeshifting tumors unmasked: New insights into master regulators reveal therapeutic vulnerabilities * Date: November 25, 2025
Here’s a breakdown of the details provided, formatted for clarity:
Research Articles:
* Patrick J. Cunniff et al. (2025). KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2.Nature Communications. DOI: 10.1038/s41467-025-66007-0
* Aktan Alpsoy et al. (2025).Structural basis of DNA-dependent coactivator recruitment by the tuft cell master regulator POU2F3. Cell Reports. DOI: 10.1016/j.celrep.2025.116572
Source:
* Provided by: Cold Spring Harbor Laboratory (https://medicalxpress.com/partners/cold-spring-harbor-laboratory/, http://www.cshl.edu/index.html)
News Article Citation:
* Title: Shapeshifting tumors unmasked: New insights into master regulators reveal therapeutic vulnerabilities
* Date: November 25, 2025