Researchers have demonstrated how mitochondria, which are abundant in muscle, could aid in stroke recovery through exercise-induced migration. Credit: Dr.Toshiki Inaba / Juntendo University School of Medicine, Japan
physical rehabilitation and symptom management still remain teh mainstay of treatment for stroke, as clot removal or dissolution is effective only within a narrow time frame after the stroke. After that, many patients are left with long-term problems like difficulty walking, speaking, and memory decline.
Exercise has been beneficial in preventing strokes and improving recovery. Though,the majority of these patients,being elderly,are to frail to exercise enough to gain these benefits.
In a study published in the journal MedComm, a team of researchers led by Research Assistant Professor Toshiki Inaba from the Department of Neurology, Juntendo University School of Medicine, Japan, along with Dr. Nobukazu Miyamoto and Dr. Nobutaka Hattori from Juntendo University School of Medicine, Japan, explored how exercise protects the brain against stroke at a biological level through mitochondrial migration.
“It was during my research fellowship with Assistant Professor Kazuhide Hayakawa at Massachusetts General Hospital/Harvard Medical School that I first observed that these mitochondria could travel from one cell to another, leading to the realization that mitochondrial transfer could be harnessed for a wide range of therapeutic applications. This motivated us to explore intercellular mitochondrial transfer as a novel treatment strategy
More details
toshiki Inaba et al, Mitochondrial Intercellular Transfer via Platelets After Physical Training Exerts Neuro‐Glial Protection Against Cerebral Ischemia, MedComm (2026). DOI: 10.1002/mco2.70590
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