More than Half of Mpox Patients in 2022 Had Lasting Physical Effects
## Mpox Long-Term Effects: Study Findings & Current Status (as of January 21, 2026)
The provided text discusses a study examining the long-term physical effects of mpox (formerly known as monkeypox). As of January 21, 2026, the findings remain largely consistent with the initial publication, though ongoing research continues to refine understanding of post-mpox conditions.
## Centers for Disease Control and Prevention (CDC) Research on Post-Mpox Conditions
A study conducted by researchers from the CDC, Columbia University’s division of Infectious Diseases, and the University of Texas Health Science Center revealed that a notable proportion of individuals diagnosed with mpox experience lingering physical effects.
### Study Methodology & Population
The research involved over 300 adults diagnosed with mpox between May 2022 and January 2023, as well as a control group of individuals at risk who remained uninfected. the study aimed to assess the prevalence and nature of persistent symptoms following acute mpox infection.
### Prevalence of Long-Term Symptoms
More than half (58%) of those diagnosed with mpox during the 2022 outbreak reported ongoing physical symptoms between 11 and 18 months after initial diagnosis. The study, published in *annals of Internal Medicine*, details these findings.## World Health Organization (WHO) Definition of Mpox & Post-Mpox Condition
Mpox is a viral zoonosis - a disease that spreads from animals to humans. The World Health Organization (WHO) defines mpox as a disease caused by the mpox virus, which is part of the orthopoxvirus family.
### Post-Mpox Condition Defined
The term “post-mpox condition” (PMC) is used to describe symptoms that persist or develop after the acute phase of mpox infection. These symptoms can vary widely in type and severity. The CDC recognizes PMC as a significant concern, and is actively researching its causes and management.
### Examples of Reported Long-Term Symptoms
Reported long-term symptoms include:
* Fatigue
* Skin lesions or scarring
* Pain (muscle, joint, or nerve)
* cognitive difficulties (“brain fog”)
* Mental health concerns (anxiety, depression)
## CDC Data on Mpox Cases & Trends (as of January 21, 2026)
As of January 21, 2026, the global mpox outbreak declared a Public Health Emergency of International concern by the WHO in July 2022 has considerably subsided. CDC data shows a significant decrease in reported cases compared to 2022,largely attributed to vaccination efforts and behavioral changes.### Vaccination & Prevention
The JYNNEOS vaccine has proven highly effective in preventing mpox infection and reducing the severity of illness. Continued vaccination and public health awareness campaigns remain crucial for controlling the spread of the virus and mitigating the risk of long-term complications.