NBA Playoffs Second Round Betting Odds and Matchups

The NBA playoffs move into the second round with several high-stakes matchups and significant injury concerns shaping the betting landscape. According to odds from DraftKings Sportsbook as of May 2, 2026, the series feature a mix of dominant favorites and unexpected survivors.

Eastern Conference: Philadelphia and New York

The Philadelphia 76ers enter their second-round series against the New York Knicks following a dramatic first-round comeback. Philadelphia had fallen behind 3-1 in their series against the second-seeded Boston Celtics after losing Games 3 and 4 on their own home court.

The 76ers recovered to win the final three games of that series, including pivotal victories in Games 5 and 7 in Boston, to eliminate the Celtics. The series conclusion was impacted by a knee injury to Jayson Tatum, who missed Game 7, and a poor shooting performance by Boston, which converted only 13-of-50 attempts from three-point range.

Philadelphia now faces New York in a matchup where both teams split their regular-season meetings, winning two games each on the opponent’s home floor. Game 1 is scheduled for May 4, 2026, in New York.

DraftKings Sportsbook lists the Knicks as the favorites with a -260 moneyline for the series, while the 76ers are at +200. For Game 1, the Knicks are favored by a spread of -5.5, with a moneyline of -218 compared to +180 for Philadelphia. The over/under for the opening game is set at 213.5 points.

Western Conference: Oklahoma City and Los Angeles

In the Western Conference, the Oklahoma City Thunder enter their series against the Los Angeles Lakers as heavy favorites. The Thunder swept the Lakers 4-0 during the regular season, winning by an average margin of 29.3 points per game, which included victories by 43 and 36 points.

The Lakers’ situation is complicated by the absence of Luka Doncic, who has not yet returned from injury. This personnel deficit has led DraftKings to set the Thunder at -1600 for the series, with the Lakers at +900. The sportsbook also lists the Thunder at +120 for the Correct score odds to sweep the Lakers in the postseason.

Game 1 takes place on May 5, 2026, in Oklahoma City. The Thunder are favored by a spread of -15.5, with a moneyline of -1100. The Lakers are listed at +700, and the over/under for the game is 213.5 points.

Western Conference: San Antonio and Minnesota

The San Antonio Spurs face the Minnesota Timberwolves in a series where the betting odds heavily favor the Spurs at -2000, while Minnesota sits at +950. This disparity exists despite Minnesota winning the regular-season series 2-1.

San Antonio advanced to the second round after defeating the Portland Trail Blazers in five games. The Spurs dealt with a brief scare when Victor Wembanyama suffered a concussion in Game 2 and missed Game 3, but he returned for the final two games of the first round.

Minnesota enters the series with significant roster challenges. Donte DiVincenzo is out for the remainder of the playoffs, and Anthony Edwards is expected to miss time in the second round due to a knee injury. Ayo Dosunmo is managing a calf strain.

Game 1 is scheduled for May 4, 2026, in San Antonio. The Spurs are favored by a spread of -13.5, with a moneyline of -900. The Timberwolves are listed at +600, with an over/under of 217.5 points.