New Protein Discovery Could Rival Ozempic With Fewer Side Effects
- In a significant development for obesity treatment, scientists have identified a naturally occurring molecule, BRP (BRINP2-related peptide), that shows promise in appetite control and weight...
- BRP functions by activating specific neurons in the brain, similarly to how GLP-1 (glucagon-like peptide-1) agonists operate.
- Laetitia Coassolo, a pathology researcher from Stanford University, spearheaded a team that developed an AI-based drug discovery program named 'Peptide predictor'.
BRP: A Potential Game Changer in Weight Loss, Competing with Ozempic
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In a significant development for obesity treatment, scientists have identified a naturally occurring molecule, BRP (BRINP2-related peptide), that shows promise in appetite control and weight loss. This molecule could perhaps rival popular GLP-1 agonists like ozempic.
How BRP Works
BRP functions by activating specific neurons in the brain, similarly to how GLP-1 (glucagon-like peptide-1) agonists operate. However, a key difference lies in the metabolic pathway each peptide utilizes.
Laetitia Coassolo, a pathology researcher from Stanford University, spearheaded a team that developed an AI-based drug discovery program named ‘Peptide predictor’. This program was instrumental in identifying 373 proteins for further investigation from a pool of thousands. The team then screened 100 peptides that could potentially induce the brain activity necessary to influence appetite.
among these candidates was the BRP molecule, a tiny peptide composed of just 12 amino acids.
BRP’s Impact on Cellular Activity
In laboratory settings, GLP-1 increased activity markers in human insulin cells threefold.A growth factor, on the other hand, increased similar activity tenfold in brain cells.
Notably, BRP elevated activity markers in both neuronal and insulin-producing cells by more than tenfold, showcasing its potent effect.
Animal Testing Results
Animal testing involving lean, male mice demonstrated that B
BRP for Weight Loss: Your Questions Answered
What is BRP?
BRP (BRINP2-related peptide) is a naturally occurring molecule identified as a potential agent for appetite control and weight loss. It is being explored as a possible choice to GLP-1 agonists like Ozempic.
How does BRP work for weight loss?
BRP works by activating specific neurons in the brain, similar to GLP-1 agonists. Though, it utilizes a different metabolic pathway. Specifically, BRP is a 12-amino acid peptide that significantly increases the activity of neuronal cells.
How was BRP discovered?
BRP was discovered using an AI-based drug revelation program called ‘Peptide predictor’ developed by Laetitia Coassolo and her team at Stanford University. The program screened thousands of proteins and identified 373 for further inquiry, eventually leading to the identification of BRP.
What is Peptide Predictor?
Peptide Predictor is an AI-based drug discovery program developed by Laetitia Coassolo, a pathology researcher from Stanford University, and her team. It was designed to identify peptides that could influence appetite by inducing brain activity.the program played a pivotal role in identifying the BRP molecule.
How effective is BRP compared to GLP-1 agonists?
In laboratory settings, while GLP-1 increased activity markers threefold in human insulin cells, and a growth factor increased activity tenfold in brain cells, BRP elevated activity markers in both neuronal and insulin-producing cells by more than tenfold. This suggests a potentially more potent effect.
what are the potential benefits of BRP compared to drugs like Ozempic?
BRP is being explored for its potential to offer weight loss benefits with potentially fewer adverse effects compared to existing drugs like Ozempic.However, more research is needed to confirm this.
Has BRP been tested on animals?
Yes, animal testing has been conducted. Initial results from testing on lean, male mice have been documented, but the