One Antibiotic Dose Enough for Early Syphilis

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single-Dose Penicillin G for Early Syphilis is Effective: A recent study found that a single dose of 2.4 million units⁤ of benzathine penicillin G⁢ (BPG) is as effective as three doses for treating early⁤ syphilis, even in people wiht HIV. Non-Inferiority Across HIV⁣ Status: Serologic response rates were‍ similar (76% in both groups) for those with HIV and those without HIV receiving a single dose, ⁤and comparable to those⁤ receiving three doses (71% and 70% respectively).
No‍ Benefit to Multiple Doses: The study’s lead⁣ author, Edward W.Hook III, MD, concluded that‍ there’s no clinical benefit to using more than a ⁤single dose of⁢ BPG. Reassurance for Clinicians: An⁣ editorial by CDC officials (Lindley A. Barbee, MD, MPH, and Laura H. Bachmann, MD, MPH) emphasized that the findings should reassure clinicians, especially those treating patients with HIV, that a single dose is sufficient.
Call for Renewed Efforts: The editorial also highlighted the need for increased focus on syphilis diagnostics and therapeutics due to⁤ its recent resurgence.
Study ⁤Source: The study was published in the New England Journal of Medicine ⁢ (2025; two: 10.1056/Nejmoa2401802).
* Disclosures: Researchers had financial ties ⁣to various organizations (listed in the text).