Oxford Researchers Uncover Gastrointestinal Stem Cell Mechanisms in Colorectal Cancer
- The published update details mechanisms behind colorectal cancer development, building upon prior work involving teams from Columbia University Medical Center, the Blizard Institute, St.
- The Gastrointestinal Stem Cell Biology Laboratory and the Molecular and Population Genetics Laboratory at the Wellcome Trust Centre for Human Genetics, University of Oxford, contributed significantly to the...
- Additional institutional contributors include Mukesh Bansal from the Department of Systems Biology at Columbia University Medical Center in New York, and researchers Tatjana Boitsova, Rosemary Jeffery, Richard Poulsom,...
The published update details mechanisms behind colorectal cancer development, building upon prior work involving teams from Columbia University Medical Center, the Blizard Institute, St. Mark’s Hospital, and University College London Hospital.
Research Contributions and Laboratory Affiliations
The Gastrointestinal Stem Cell Biology Laboratory and the Molecular and Population Genetics Laboratory at the Wellcome Trust Centre for Human Genetics, University of Oxford, contributed significantly to the work. Hayley Davis and Shazia Irshad contributed equally as authors from the Oxford Gastrointestinal Stem Cell Biology Laboratory, alongside colleagues Hannah Rafferty, Tatjana Boitsova, Pedro Rodenas-Cuadrado, and Simon J. Leedham.
Additional institutional contributors include Mukesh Bansal from the Department of Systems Biology at Columbia University Medical Center in New York, and researchers Tatjana Boitsova, Rosemary Jeffery, Richard Poulsom, and Andrew Silver from the Centre for Digestive Diseases, Blizard Institute, Barts and the London School of Medicine and Dentistry in Whitechapel, London.
Clinical and International Collaborators
The study also integrated teams from molecular and population genetics at Oxford—including Chiara Bardella, Emma Jaeger, Annabelle Lewis, Luke Freeman-Mills, Francesc C. Giner, and Ian Tomlinson—as well as clinical registries and pathology departments.
The Polyposis Registry at St. Mark’s Hospital in Harrow was represented by Sreelakshmi Mallappa, Susan Clark, and Huw Thomas. Manuel Rodriguez-Justo and Marco Novelli contributed from the Department of Histopathology at University College London Hospital. Further international academic participation involved Runjan Chetty from the Laboratory Medicine Program at the University Health Network and University of Toronto in Ontario, Canada, Owen J. Sansom from the Beatson Institute for Cancer Research in Bearsden, Glasgow, and Florian R. Greten from the Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy in Frankfurt, Germany.
Additional clinical pathology and translational inputs were provided by Lai Mun Wang from Cellular Pathology at John Radcliffe Hospital in Headington, Oxford, alongside James E. East and Simon J. Leedham from the Translational Gastroenterology Unit within the Nuffield Department of Clinical Medicine at John Radcliffe Hospital. Ian Tomlinson additionally represented the Oxford National Institute for Health Research Comprehensive Biomedical Research Centre at the Wellcome Trust Centre for Human Genetics.