Recreational Drug Use & Heart Attack Outcomes
- Michael Aboujaoude, MD, phd candidate at Université Paris Cité, University Hospital of Lariboisiere in Paris, and colleagues wrote.
- ADDICT-ICCU was a multicenter, prospective, observational study including all consecutive adult patients admitted to intensive cardiac care units at 39 centers across France during a 2-week period in...
- As Healio previously reported, recreational use of cannabis, opioids, cocaine and amphetamines was prevalent in 11% of patients admitted to cardiac ICUs; tied to increased odds of in-hospital...
January 28, 2026
2 min read
Michael Aboujaoude, MD, phd candidate at Université Paris Cité, University Hospital of Lariboisiere in Paris, and colleagues wrote. “In intensive cardiac care unit patients with STEMI, drug detection was independently associated with a considerably higher risk of MACE, including ventricular arrhythmia. While these findings demonstrate the short-term impact of recreational drug use on intensive cardiac care unit patients, the long-term impact, specifically in ACS patients and its subgroups, remains unclear.”
ADDICT-ICCU and prior evidence
Table of Contents
ADDICT-ICCU was a multicenter, prospective, observational study including all consecutive adult patients admitted to intensive cardiac care units at 39 centers across France during a 2-week period in April 2021.
As Healio previously reported, recreational use of cannabis, opioids, cocaine and amphetamines was prevalent in 11% of patients admitted to cardiac ICUs; tied to increased odds of in-hospital major adverse events; and only half of admitted patients who used these drugs disclosed it to their care team.
In addition, Raphaël Mirailles, MD, from Hospital Lariboisiere, Paris, and co-author on the present study, presented another ADDICT-ICCU analysis at the 2024 european society of Cardiology Congress indicating that among patients admitted to the cardiac ICU, those engaging in recreational drug use were almost threefold more likely to experience a repeat serious CV event within 1 year vs. nonusers.
Aboujaoude, Mirailles and colleagues designed the present study to evaluate the 1-year impact of recreational drug use among patients admitted to the cardiac ICU with ACS, focusing on non-STEMI and STEMI presentations.
recreational drug use and outcomes after ACS
The primary outcome was MACE, defined as CV death, nonfatal MI or stroke.
The ADDICT-ICCU study included 712 patients admitted with ACS (mean age, 64 years; 75% men) of which 13.5% had recreational drug detection on urine analysis.
Among patients who tested positive for recreational drug use,34 used opioids,18 used stimulants,eight used depressants,86 used THC and some patients tested positive for multiple substances.
At 1 year, the primary outcome occurred in 7% of the cohort, at a twofold higher rate among patients who tested positive for recreational drug use compared with nonusers (12.5% vs. 6.2%; HR = 2.7; 95% CI, 1.3-5.57; P = .013), according to the study.
The association between recreational drug use and MACE in the year following ACS was notable for patients with STEMI (HR = 4.11; 95% CI,1.6-10.5; P =.005),but not for those
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