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Sacituzumab Tirumotecan + Tagitanlimab for Advanced NSCLC - News Directory 3

Sacituzumab Tirumotecan + Tagitanlimab for Advanced NSCLC

August 19, 2025 Jennifer Chen Health
News Context
At a glance
  • Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
  • Updated analysis from KEYNOTE-189: pembrolizumab or placebo plus pemetrexed and platinum for previously untreated metastatic nonsquamous non-small-cell lung cancer.
  • Atezolizumab in combination with carboplatin and nab-paclitaxel in advanced squamous NSCLC (IMpower131): results from a randomized phase III trial.
Original source: nature.com
  • Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J. Clin. 74229–263 (2024).

    PubMed

    Google Scholar

  • Gadgeel, S. et al. Updated analysis from KEYNOTE-189: pembrolizumab or placebo plus pemetrexed and platinum for previously untreated metastatic nonsquamous non-small-cell lung cancer. J. Clin. Oncol. 381505–1517 (2020).

    CAS
    PubMed

    Google Scholar

  • Jotte, R. et al. Atezolizumab in combination with carboplatin and nab-paclitaxel in advanced squamous NSCLC (IMpower131): results from a randomized phase III trial. J. Thorac. Oncol. 151351–1360 (2020).

    CAS
    PubMed

    Google Scholar

  • Gandhi, L. et al. Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer. N. Engl. J. Med. 3782078–2092 (2018).

    CAS
    PubMed

    Google Scholar

  • Paz-Ares, L. et al. Pembrolizumab plus chemotherapy for squamous non-small-cell lung cancer. N. Engl. J. Med. 3792040–2051 (2018).

    CAS
    PubMed

    Google Scholar

  • Hellmann, M. D. et al. Nivolumab plus ipilimumab in advanced non-small-cell lung cancer. N. Engl. J. Med. 3812020–2031 (2019).

    CAS
    PubMed

    Google Scholar

  • Sharma, P., Hu-Lieskovan, S., Wargo, J. A. & Ribas, A. Primary, adaptive, and acquired resistance to cancer immunotherapy. Cell 168707–723 (2017).

    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Schoenfeld, A. J. et al. Clinical definition of acquired resistance to immunotherapy in patients with metastatic non-small-cell lung cancer. Ann. Oncol. 321597–1607 (2021).

    CAS
    PubMed

    Google Scholar

  • de Castro, G. Jr et al. Five-year outcomes with pembrolizumab versus chemotherapy as first-line therapy in patients with non-small-cell lung cancer and programmed death ligand-1 tumor proportion score ≥1% in the KEYNOTE-042 study. J. Clin. Oncol. 411986–1991 (2023).

    PubMed

    Google Scholar

  • Borghaei, H. et al. Five-year outcomes from the randomized, phase III trials CheckMate 017 and 057: nivolumab versus docetaxel in previously treated non-small-cell lung cancer. J. Clin. Oncol. 39723–733 (2021).

    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Novello, S. et al. Pembrolizumab plus chemotherapy in squamous non-small-cell lung cancer: 5-year update of the phase III KEYNOTE-407 study. J. Clin. Oncol. 411999–2006 (2023).

    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Brahmer, J. R. et al. Five-year survival outcomes with nivolumab plus ipilimumab versus chemotherapy as first-line treatment for metastatic non-small-cell lung cancer in CheckMate 227. J. Clin. Oncol. 411200–1212 (2023).

    CAS
    PubMed

    Google Scholar

  • Paul, S. et al. Cancer therapy with antibodies. Nat. Rev. Cancer 24399–426 (2024).

    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Goldenberg, D. M., Stein, R. & Sharkey, R. M. The emergence of trophoblast cell-surface antigen 2 (TROP-2) as a novel cancer target. Oncotarget 928989–29006 (2018).

    PubMed
    PubMed Central

    Google Scholar

  • Bessede, A. et al. TROP2 is associated with primary resistance to immune checkpoint inhibition in patients with advanced non-small cell lung cancer. Clin. Cancer Res. 30779–785 (2024).

    CAS
    PubMed

    Google Scholar

  • Parisi, C., Mahjoubi, L., Gazzah, A. & Barlesi, F. TROP-2 directed antibody-drug conjugates (ADCs): the revolution of smart drug delivery in advanced non-small cell lung cancer (NSCLC). Cancer Treat. Rev. 118102572 (2023).

    CAS
    PubMed

    Google Scholar

  • Jiang, Y. et al. Progress and innovative combination therapies in Trop-2-targeted ADCs. Pharmaceutocals (Basel) 17652 (2024).

    CAS

    Google Scholar

  • Cheng, Y. et al. Preclinical profiles of SKB264, a novel anti-TROP2 antibody conjugated to topoisomerase inhibitor, demonstrated promising antitumor efficacy compared to IMMU-132. Front. Oncol. 12951589 (2022).

    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Fang, W. et al. SKB264 (TROP2-ADC) for the treatment of patients with advanced NSCLC: efficacy and safety data from a phase 2 study. J. Clin. Oncol. 419114 (2023).

    Google Scholar

  • Fang, W. et al. Abstract CT247: updated efficacy and safety of anti-TROP2 ADC SKB264. Cancer Res. 84CT247 (2024).

    Google Scholar

  • Müller, P. et al. Microtubule-depolymerizing agents used in antibody–drug conjugates induce antitumor immunity by stimulation of dendritic cells. Cancer Immunol. Res. 2741–755 (2014).

    PubMed

    Google Scholar

  • Rios-Doria, J. et al. Antibody–drug conjugates bearing pyrrolobenzodiazepine or tubulysin payloads are immunomodulatory and synergize with multiple immunotherapies. Cancer Res. 772686–2698 (2017).

    CAS
    PubMed

    Google Scholar

  • Wei, Q. et al. The promise and challenges of combination therapies with antibody–drug conjugates in solid tumors. J. Hematol. Oncol. 171 (2024).

    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Yin, Y. et al. Abstract OT1-03-02: efficacy and safety of SKB264 for previously treat ed metastatic triple negative breast cancer in Phase 2 study. Cancer Res. 83OT1-03-02 (2023).

    Google Scholar

  • D’Amico, L. et al. A novel anti-HER2 anthracycline-based antibody–drug conjugate induces adaptive anti-tumor immunity and potentiates PD-1 blockade in breast cancer. J. Immunother. Cancer 716 (2019).

    PubMed
    PubMed Central

    Google Scholar

  • Iwata, T. N. et al. A HER2-targeting antibody–drug conjugate, trastuzumab deruxtecan (DS-8201a), enhances antitumor immunity in a mouse model. Mol. Cancer Ther. 171494–1503 (2018).

    CAS
    PubMed

    Google Scholar

  • Junttila, T. T., Li, G., Parsons, K., Phillips, G. L. & Sliwkowski, M. X. Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer. Breast Cancer Res. Treat. 128347–356 (2011).

    CAS
    PubMed

    Google Scholar

  • Vafa, O. et al. An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations. Methods 65114–126 (2014).

    CAS
    PubMed

    Google Scholar

  • Reck, M. et al. Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. N. Engl. J. Med. 3751823–1833 (2016).

    CAS
    PubMed

    Google Scholar

  • Lau, S. C. M., Pan, Y., Velcheti, V. & Wong, K. K. Squamous cell lung cancer: current landscape and future therapeutic options. Cancer Cell 401279–1293 (2022).

    CAS
    PubMed

    Google Scholar

  • Shimizu, T. et al. First-in-human, phase I dose-escalation and dose-expansion study of trophoblast cell-surface antigen 2-directed antibody–drug conjugate datopotamab deruxtecan in non-small-cell lung cancer: TROPION-PanTumor01. J. Clin. Oncol. 414678–4687 (2023).

    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Heist, R. S. et al. Therapy of advanced non-small-cell lung cancer with an SN-38-anti-Trop-2 drug conjugate, sacituzumab govitecan. J. Clin. Oncol. 352790–2797 (2017).

    CAS
    PubMed

    Google Scholar

  • Shi, Y. et al. Efficacy and safety of KL-A167 in previously treated recurrent or metastatic nasopharyngeal carcinoma: a multicenter, single-arm, phase 2 study. Lancet Reg. Health West. Pac. 31100617 (2023).

    PubMed

    Google Scholar

  • Lababede, O. & Meziane, M.A. The eighth edition of TNM staging of lung cancer: reference chart and diagrams. Oncologist 23844–848 (2018).

    PubMed
    PubMed Central

    Google Scholar

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