Seladelpar Reduces Pruritus in Primary Biliary Cholangitis
- May suggests a new approach to treating primary biliary cholangitis (PBC) with moderate to severe itching.
- * Treatment Strategy: UDCA + seladelpar, with a waiting period to assess response.
Here’s a breakdown of the key details from the provided text:
Main Point:
dr. May suggests a new approach to treating primary biliary cholangitis (PBC) with moderate to severe itching. Rather of instantly adding multiple medications, she recommends starting with UDCA and then adding seladelpar. they should then wait 1-6 months to see if both biochemical markers and the patient’s itching improve. This could potentially reduce the number of medications a patient needs to take.
Key Details:
* Treatment Strategy: UDCA + seladelpar, with a waiting period to assess response.
* Goal: Simplify treatment by potentially using only two drugs (UDCA and seladelpar).
* If Itching Persists: Another medication for itch relief may be added.
* Source of Information: Presented at the ACG Annual Scientific Meeting (October 24-29, 2025, Phoenix). Based on a pooled analysis from the RESPONSE and ENHANCE studies.
* Disclosure: Dr. Mayo has consulting relationships with several pharmaceutical companies (CymaBay Therapeutics, GSK, Intra-Sana, ipsen, Mirum Pharma and Target PharmaSolutions).
Contact Information:
* Marlyn J. Mayo, MD: gastroenterology@healio.com
Publisher:
* Healio (specifically Healio Gastroenterology)