The increasing use of glucagon-like peptide-1 (GLP-1) receptor agonists, such as Ozempic and Mounjaro, for weight loss has become a prominent topic in recent years. While these medications can be effective for weight management, they are also associated with potential side effects, including noticeable changes in facial appearance – a phenomenon increasingly referred to as “Ozempic face.” This article will explore the effects of these medications, particularly Mounjaro, on facial structure and overall health, drawing from recent observations and patient experiences.
GLP-1 Receptor Agonists and Weight Loss
GLP-1 receptor agonists were originally developed to treat type 2 diabetes by helping to regulate blood sugar levels. However, they were also found to promote weight loss, leading to their off-label use for this purpose. Medications like Ozempic and Mounjaro work by mimicking the effects of the naturally occurring GLP-1 hormone, which signals the brain to reduce appetite and increases insulin release. Sunny Hostin, co-host of “The View,” publicly shared her experience using Mounjaro after gaining 40 pounds during the COVID-19 pandemic, highlighting the appeal of these drugs for rapid weight loss.
The Emergence of “Ozempic Face”
Rapid weight loss, while often desired, can have a significant impact on facial structure. As fat is lost, particularly from the face, the skin can lose volume, leading to a more gaunt appearance. This can accentuate wrinkles, create a sunken look in the cheeks, and make facial features appear more pronounced. This collection of changes has been dubbed “Ozempic face.” In Hostin’s case, side-by-side images from 2015 and 2025 show that while her features remained recognizable, they appeared sharper and more defined after using Mounjaro. Her cheeks appeared somewhat sunken, and lines around her nose and mouth became more visible.
Beyond Facial Changes: Side Effects and Discontinuation
While some individuals may be willing to accept the cosmetic changes associated with GLP-1 receptor agonists, other side effects can be more problematic. Common side effects include nausea, diarrhea, abdominal pain, and vomiting. More serious complications, though less frequent, can include stomach paralysis, gallbladder issues, and gastrointestinal diseases. Hostin herself discontinued Ozempic due to a significant side effect: severe constipation. She described the constipation as “horrible” and necessitating a consultation with her doctor. The medication proved ineffective for her weight loss goals, prompting her physician to switch her to a different treatment.
Experiences of Other Celebrities
Hostin is not alone in her experience with GLP-1 receptor agonists. Whoopi Goldberg, also a co-host of “The View,” has also spoken positively about her experience with Mounjaro, noting significant weight loss. However, Goldberg also exhibits changes consistent with “Ozempic face,” suggesting that these facial effects are not uncommon among users. The experiences of these public figures have contributed to a broader conversation about the benefits and drawbacks of these medications.
Open Dialogue and Acceptance
A recent discussion on “The View,” featuring Oprah Winfrey, highlighted a growing trend toward openness about using weight loss medications. Winfrey shared her own journey and expressed a desire to destigmatize the use of these drugs. The conversation centered on the challenges of body image, shame, and the acceptance of different approaches to weight management. This shift in perspective suggests a growing willingness to acknowledge the role of medication in weight loss and to address the associated challenges openly.
Understanding the Mechanism Behind Facial Changes
The facial changes observed with GLP-1 receptor agonists are primarily due to the loss of subcutaneous fat. This fat layer provides support and volume to the face. When it diminishes, the underlying bone structure becomes more prominent, and the skin can appear looser. The rapid nature of weight loss with these medications can exacerbate these effects, as the skin does not have time to adjust. While the changes are not necessarily harmful, they can be aesthetically concerning for some individuals.
The Importance of Medical Supervision
The experiences of Sunny Hostin and others underscore the importance of medical supervision when using GLP-1 receptor agonists. These medications are powerful drugs with potential side effects, and their use should be carefully monitored by a healthcare professional. Regular check-ups can help identify and manage any adverse effects, and adjustments to the treatment plan can be made as needed. A comprehensive approach to weight management, including diet and exercise, is crucial for long-term success and overall health.
The rise in popularity of GLP-1 receptor agonists for weight loss presents both opportunities and challenges. While these medications can be effective for weight management, it’s crucial to be aware of the potential side effects, including facial changes, and to approach their use with caution and under the guidance of a healthcare professional. The ongoing conversation among public figures like Sunny Hostin, Whoopi Goldberg, and Oprah Winfrey is helping to normalize the discussion around weight loss medications and to promote a more informed and accepting approach to weight management.
