TB Diagnosis After Multiple Transplants from Same Donor
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Summary:
This article reports on a case of three organ transplant recipients who contracted tuberculosis (TB) from the same deceased donor. The donor,originating from a TB-endemic area,was not screened for TB before their organs (kidneys and liver) were transplanted. the recipients developed TB within six weeks of their transplants, highlighting the risk of donor-derived TB and the need for improved screening protocols. All three patients survived, but experienced significant medical complications.
Key Details:
The Incident: Three patients contracted TB after receiving organs from a single deceased donor.
Donor Background: The donor was from a TB-endemic area and had not been screened for TB. Chest CT scans showed abnormalities (consolidations and opacities) initially attributed to aspiration pneumonia and Klebsiella pneumoniae infection.
Recipients:
One recipient (woman in her 50s) had a prior history of TB treatment.
Two recipients (men in their 70s) had no prior history of TB.
symptoms & Diagnosis: All three patients developed unexplained fevers and othre symptoms within six weeks of transplant. Initial antibacterial treatment failed, and subsequent testing confirmed Mycobacterium tuberculosis infection.
Treatment: One recipient required removal of the transplanted kidney due to the TB infection.
Expert Opinion (Dr. Paulina Vega): Donor-derived TB is rare but serious, and raising awareness among clinicians is crucial due to diagnostic challenges.
Call to Action: The case underscores the need for improved TB screening in organ donors, especially those from endemic areas. Source: the information is based on a paper by Vega et al. published in Open Forum Infectious Diseases.
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