Tear Volume & Lipids Increase with Tryptyr Use in Dry Eye
- here's a breakdown of the key details from the article, focusing on the points you'd likely be interested in:
- * New Treatment: alcon has launched Tryptyr (Acoltremon 0.003%) in the US for dry eye.
- He prefers non-invasive measurements like tear meniscus height (measured with OCT).
here’s a breakdown of the key details from the article, focusing on the points you’d likely be interested in:
Key Takeaways about Tryptyr (Acoltremon 0.003%) for Dry Eye:
* New Treatment: alcon has launched Tryptyr (Acoltremon 0.003%) in the US for dry eye.
* Mechanism of Action: It stimulates nerve endings to increase natural tear production. This stimulation can cause a temporary burning/stinging sensation (reported by 39% of patients in the study).
* Doctor Recommendation: Both Dr. Nate Lighthizer and Dr. Cory Lappin are enthusiastic about the drug. Dr. Lighthizer says he’s prescribing it to most of his patients, and Dr. Lappin believes almost all dry eye patients would benefit.
* Focus on Basal Tears: The doctors emphasize the importance of increasing natural tear production because basal tears contain essential healthy components.
Diagnostic Preferences – OCT vs. Schirmer Testing:
* OCT Preferred: Dr. Lighthizer doesn’t use Schirmer testing. He prefers non-invasive measurements like tear meniscus height (measured with OCT).
* Why OCT? Schirmer testing can cause reflex tearing, which isn’t a true measure of natural tear production. OCT allows assessment of tear production without touching the eye.
* Lipid Data: The study showed an increase in tear lipid concentration with Tryptyr, which is considered clinically meaningful as it indicates a more complete and healthy tear film.
Study Details:
* Study Presented: Results from a Phase 3b study were presented at the Academy 2025 conference (Oct.8-11, 2025, Boston).
* Findings: Acoltremon 0.003% led to statistically significant increases in tear volume and tear total lipid concentration.
Disclosures:
* Dr. lappin has a consulting relationship with Alcon.
* Dr. Lighthizer has a financial relationship with alcon.
Contact Information:
* cory Lappin, OD, MS, FAL: coryjlappin@gmail.com, Instagram @cory.lappin, LinkedIn at Cory Lappin, OD, MS, FAAO
* Nate Lighthizer, Oid, Pat: lighthiz@nsuok.edu