Automated Insulin Delivery Systems Improve ⁣Blood⁣ Sugar Control in Type 1 ‍Diabetes, Study ⁣Finds

Düsseldorf, Germany (April 30, 2025) – A thorough meta-analysis ‍indicates ‍that automated insulin‍ delivery (AID) systems significantly ⁤improve blood glucose management for individuals with Type 1⁢ diabetes compared too conventional ⁤insulin therapies. The study, ⁢evaluating 46 clinical trials‍ involving ⁢4,113⁢ participants, represents the most extensive review⁤ of its kind to⁣ date.

AID systems: A⁢ Closer ⁣Look

The research focused on Hybrid closed Loop (HCL), Advanced Hybrid Closed⁢ Loop (AHCL),⁣ and Full Closed Loop⁣ (FCL)⁢ systems, frequently enough referred to as an artificial pancreas.These⁢ systems integrate ⁤continuous glucose monitoring with automated insulin governance, adjusting insulin ⁤levels ⁢in real-time based on glucose readings.

Key Findings

The study revealed that AID systems increased the time individuals spent within their target ⁤glucose range compared⁣ to conventional pump therapy. Specifically, AHCL systems, the most prevalent type of AID system, increased time in the target range by an average of 24%. These systems ⁤also reduced the amount of time spent with elevated glucose⁣ levels‍ (above 180 mg/dL and 250 mg/dL) when‍ compared to traditional‍ pump⁤ methods.

researchers ‍also noted improvements in HbA1c levels among those using AHCL systems. While the findings suggest a clear ⁢benefit, the authors caution that future research could refine these assessments. The study indicated limited effectiveness ⁢in preventing very low glucose levels (below 70 ‍mg/dL and 54 mg/dL), highlighting the need for further examination in this area.

Implications for Diabetes Management

According to Prof. Dr. Michael ⁢Roden, scientific managing director and spokesman for the board, the study offers valuable data for clinical ‍decision-making and ⁤collaborative ⁤therapy selection between patients and healthcare providers. Roden also directs the clinic for Endocrinology and Diabetology at the University Hospital Düsseldorf (UKD).

Dr. ⁢Anna stahl-Pehen, the study’s lead ⁤author, added‍ that while AID systems offer overall advantages,⁣ their⁢ effectiveness varies across different‍ targets. She emphasized the ⁣ongoing nature of AID system research.

original publication

The original research article is: Stahl-Pehe A, Shokri-Mashhadi N, Wirth M, Schlesinger S, Kuss O, Holl‍ RW, Bächle C, Warz K-D, Bürger-Büsing J, Spörkel O, Rosenbauer J. 2025. Efficacy of automated insulin delivery systems in ⁢people with ⁣type⁣ 1 diabetes: a systematic review ‍and⁣ network ⁤meta-analysis of outpatient randomised controlled trials. eClinicalMedicine. 82:103190.