Urine Test for Renal Cancer Recurrence
- A new study suggests that a simple urine test could help detect the recurrence of kidney cancer in patients who have undergone surgery, potentially reducing the need for...
- The study, known as Aur87A, involved 134 patients treated across 23 hospitals in the United Kingdom, Europe, the United States, and Canada.
- Approximately 20% of patients with this form of cancer experience a recurrence, typically within the first two years following surgery.
Simple Urine Test Shows Promise in Detecting Kidney Cancer Recurrence
Table of Contents
- Simple Urine Test Shows Promise in Detecting Kidney Cancer Recurrence
- Simple Urine Test Shows Promise in Detecting Kidney Cancer Recurrence: Q&A
- Can Kidney Cancer Recur After Treatment?
- How is Kidney Cancer Recurrence Currently Monitored?
- What is the new urine test for detecting kidney cancer recurrence?
- How Effective is the Urine Test in Detecting Kidney Cancer Recurrence?
- Where has this urine test been tested?
- What are the potential benefits of using this urine test?
- how does the urine test work?
- What are the next steps for this urine test?
- Summary of key Findings
A new study suggests that a simple urine test could help detect the recurrence of kidney cancer in patients who have undergone surgery, potentially reducing the need for frequent CT scans.
International Study Details
The study, known as Aur87A, involved 134 patients treated across 23 hospitals in the United Kingdom, Europe, the United States, and Canada. All patients had been diagnosed with clear cell renal cell carcinoma (CCRCC), the most common type of kidney cancer, which had not spread beyond the kidneys and was treated surgically.
Approximately 20% of patients with this form of cancer experience a recurrence, typically within the first two years following surgery. Current monitoring methods rely on computerized tomography (CT) scans, with the frequency determined by individual risk factors.
Urine Test and Risk Assessment
As part of the study, patients continued their standard CT scan monitoring while also undergoing a urine test every three months. This test analyzed the levels of specific sugar molecules in the urine, called glycosaminoglycans, and generated a risk score, known as the Gagome score, ranging from zero to 100.
After 18 months,15% of the patients experienced a cancer relapse. The urine test accurately detected cancer recurrence in 90% of these cases. Moreover, the test successfully ruled out recurrence in slightly over half of the patients who remained cancer-free.
potential Benefits of the Urine Test
According to Saeed Dabestani, an associate professor from Lund University and a urologist at Kristiastad Central Hospital in Sweden, the urine test could significantly improve the management of cancer recurrence.
computerized tomographs often identify lesions too small to biopsy, and we do not know if these are signs of cancer recurrence or not. The only option is more frequent monitoring through additional scans, which is unpleasant to patients and frequently enough does not bring critically importent benefits.
Saeed Dabestani, Lund University and Kristiastad Central Hospital
If we have a urine test that can look precisely if the disease has returned, we can better evaluate the risk level and reduce the frequency of the necessary tomographs. Based on the results so far, it is likely that the number of scans can be reduced to half without risks.
Saeed Dabestani, Lund University and Kristiastad Central Hospital
Future Research
The findings of this study are slated for presentation at the Congress of the European Urology Association (EAU) in Madrid and have been accepted for publication in the journal *European Urology Oncology*.Researchers are currently enrolling a second group of patients to continue the Aur87A study, with new results anticipated later this year.
Simple Urine Test Shows Promise in Detecting Kidney Cancer Recurrence: Q&A
Can Kidney Cancer Recur After Treatment?
Yes, kidney cancer can recur even after successful treatment, such as surgery. The risk of recurrence is a critically important concern for patients. Approximately 20% of patients wiht clear cell renal cell carcinoma (CCRCC), the most common type of kidney cancer, experience a recurrence, typically within the first two years following surgery.
How is Kidney Cancer Recurrence Currently Monitored?
Current monitoring methods for kidney cancer recurrence primarily rely on computerized tomography (CT) scans. The frequency of these scans is resolute by individual risk factors.However, CT scans can sometimes identify questionable lesions, leading to increased monitoring and potential patient anxiety.
What is the new urine test for detecting kidney cancer recurrence?
A new urine test shows promise in detecting the recurrence of kidney cancer. This non-invasive test analyzes the levels of specific sugar molecules in the urine,called glycosaminoglycans,to generate a risk score,known as the Gagome score.
How Effective is the Urine Test in Detecting Kidney Cancer Recurrence?
The urine test demonstrated a high degree of accuracy in detecting cancer recurrence. In a study known as Aur87A, the urine test accurately detected cancer recurrence in 90% of the cases.The test also successfully ruled out recurrence in slightly over half of the patients who remained cancer-free.
Where has this urine test been tested?
The study involved 134 patients across 23 hospitals in the United Kingdom,Europe,the United States,and Canada who had been diagnosed with clear cell renal cell carcinoma (CCRCC) which had not spread beyond the kidneys and was treated surgically.
What are the potential benefits of using this urine test?
The urine test could considerably improve the management of cancer recurrence by:
Reducing the need for frequent CT scans: The urine test could help to determine the risk level and reduce the frequency of necessary CT scans significantly. According to Saeed Dabestani, the frequency of scans can likely be reduced to half without risks.
Avoiding the uncertainty of CT scans: CT scans can sometimes identify lesions too small to biopsy, making it tough to determine if the cancer has returned.
* Improving patient experience: Reducing the frequency of CT scans can improve the patient experience.
how does the urine test work?
The urine test analyzes the levels of specific sugar molecules in the urine, called glycosaminoglycans, and generates a risk score, known as the gagome score.
What are the next steps for this urine test?
Researchers are currently enrolling a second group of patients to continue the Aur87A study, with new results anticipated later this year. The findings of this study are slated for presentation at the Congress of the European Urology Association (EAU).
Summary of key Findings
| Feature | Details |
| ——————- | —————————————————————————————————————————————— |
| Cancer Type | Clear cell renal cell carcinoma (CCRCC) |
| Study Population | 134 patients across 23 hospitals in the UK, US, Europe and Canada, previously treated with surgery. |
| Test Method | Urine test analyzing glycosaminoglycans (GAGomes) |
| Accuracy | 90% of cases accurately detected recurrence |
| Potential Benefit | Reduce the need for frequent CT scans, can better evaluate the risk level |