Young Women & Long COVID: Higher POTS Risk | The Transmission
Long COVID Linked to Increased POTS Risk in Young Women
Table of Contents
Updated October 16,2025
Understanding the Connection
Research indicates a significant association between long COVID and postural orthostatic tachycardia syndrome (POTS),especially among young women. A prospective analysis of 467 nonhospitalized individuals experiencing persistent symptoms following COVID-19 revealed a notable incidence of POTS.
The study, published in Circulation: Arrhythmia and Electrophysiology, focused on a cohort where 91% were middle-aged women who were previously healthy and physically active. Evaluations, including electrocardiograms, head-up tilt tests, and Active Stand Tests, were conducted at a median of 12 months post-acute COVID-19 infection to identify POTS cases.
Impact on Physical Function
Individuals with long COVID and POTS demonstrated substantially reduced physical activity levels and capacity compared to those with long COVID who did not develop POTS. This suggests that the co-occurrence of POTS exacerbates the functional limitations experienced by those with long-term COVID-19 symptoms.
Study Methodology
The research involved a detailed cardiologist evaluation for patients with clinically suspected POTS.This included a 48-hour electrocardiogram to monitor heart activity, a head-up tilt test to assess blood pressure and heart rate response to postural changes, and an Active Stand test to evaluate orthostatic tolerance.
