A Natural Aging Molecule Restores Memory in Alzheimer’s
- Researchers at the National University of Singapore (NUS) have found that calcium alpha-ketoglutarate (CaAKG), a compound initially studied for its potential to extend healthy lifespan, may improve synaptic...
- Synaptic plasticity, the brain's ability to strengthen or weaken connections between neurons, is crucial for learning and memory.
- Detail: CaAKG is a modified amino acid that plays a role in cellular metabolism and epigenetic regulation. Research indicates it can influence histone acetylation, a process that alters...
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Calcium Alpha-Ketoglutarate Shows Promise in Alzheimer’s Research
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Researchers at the National University of Singapore (NUS) have found that calcium alpha-ketoglutarate (CaAKG), a compound initially studied for its potential to extend healthy lifespan, may improve synaptic plasticity and protect memory in the context of Alzheimer’s disease. The findings, published in 2024, suggest a potential new avenue for slowing brain aging and mitigating the effects of the disease.
CaAKG and Synaptic Plasticity
Synaptic plasticity, the brain’s ability to strengthen or weaken connections between neurons, is crucial for learning and memory. Alzheimer’s disease disrupts this process, leading to cognitive decline. CaAKG appears to enhance synaptic plasticity, perhaps counteracting these detrimental effects.
Detail: CaAKG is a modified amino acid that plays a role in cellular metabolism and epigenetic regulation. Research indicates it can influence histone acetylation, a process that alters gene expression and can impact neuronal function. The study focused on how CaAKG affects the synapses,the junctions between nerve cells where communication occurs.
Example: The study, led by Dr.Sheeja Navakkode, demonstrated that CaAKG treatment improved synaptic function in preclinical models.NUS News reported on the findings in February 2024, detailing the observed improvements in synaptic strength and cognitive performance.
National university of Singapore (NUS) and Healthy longevity TRP
The National University of Singapore (NUS) is a leading research university in Asia,consistently ranked among the top universities globally. NUS official website. The research was conducted by scientists at the Healthy Longevity TRP (translational research program) within NUS Medicine.
Detail: The Healthy Longevity TRP is dedicated to research aimed at understanding the biological processes of aging and developing interventions to promote healthy aging and prevent age-related diseases.The program focuses on translating scientific discoveries into practical applications for improving human healthspan.
Example: the Healthy Longevity TRP is part of a larger initiative funded by the Singapore Ministry of Health to address the challenges of an aging population. Singapore Ministry of Health press release announced the program’s launch in 2023, outlining its goals and scope.
Alzheimer’s Disease and Current Treatments
Alzheimer’s disease is a progressive neurodegenerative disorder that affects millions worldwide. Currently available treatments primarily address symptoms but do not halt or reverse the underlying disease process. Alzheimer’s Association provides comprehensive facts on the disease and current treatment options.
Detail: The hallmark of Alzheimer’s disease is the accumulation of amyloid plaques and tau tangles in the brain, leading to neuronal damage and cognitive decline. Research efforts are focused on developing therapies that target these pathological processes, and also strategies to enhance neuronal resilience and protect synaptic function.
Example: As of January 26, 2026, the U.S. Food and Drug Administration (FDA) has approved several disease-modifying therapies for Alzheimer’s disease, including aducanumab and lecanemab, which aim to reduce amyloid plaque buildup.