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Microsoft Azure Launches NDv6 GB300 VMs Powered by NVIDIA GB300 NVL72 for AI Inference
Microsoft Azure today announced the new NDv6 GB300 VM series, delivering the industry’s first supercomputing-scale production cluster of NVIDIA GB300 NVL72 systems, purpose-built for OpenAI’s most demanding AI inference workloads.
This supercomputer-scale cluster features over 4,600 NVIDIA Blackwell ultra GPUs connected via the NVIDIA Quantum-X800 InfiniBand networking platform. Microsoft’s unique systems approach applied radical engineering too memory and networking to provide the massive scale of compute required to achieve high inference and training throughput for reasoning models and agentic AI systems.
Today’s achievement is the result of years of deep partnership between NVIDIA and Microsoft purpose-building AI infrastructure for the world’s most demanding AI workloads and to deliver infrastructure for the next frontier of AI. It marks another leadership moment, ensuring that leading-edge AI drives innovation in the United States.
“Delivering the industry’s first at-scale NVIDIA GB300 NVL72 production cluster for frontier AI is an achievement that goes beyond powerful silicon – it reflects Microsoft Azure and NVIDIA’s shared commitment to optimize all parts of the modern AI data center,” said Nidhi Chappell, corporate vice president of Microsoft Azure AI Infrastructure.
“our collaboration helps ensure customers like OpenAI can deploy next-generation infrastructure at unprecedented scale and speed.”
Inside the Engine: The NVIDIA GB300 NVL72
At the heart of Azure’s new NDv6 GB300 VM series is the liquid-cooled, rack-scale NVIDIA GB300 NVL72 system. Each rack
