Breakthrough Mushroom Supplement Shown to Inhibit Prostate Cancer Growth: Discover the Science Behind This Natural Remedy

Researchers at City of Hope have discovered that white button mushrooms may help slow the progression of prostate cancer. This finding is based on a phase 2 clinical trial that explores the use of food as a medicinal treatment. The study indicates that white button mushroom supplements can reduce a type of immune cell known as myeloid-derived suppressor cells (MDSCs). These cells can suppress the immune response and promote cancer growth.

The study combined laboratory findings with preliminary human data. City of Hope researchers found that using white button mushrooms can lead to a decrease in MDSCs and an increase in anti-tumor T cells and natural killer cells. This suggests that these mushrooms may help rebuild the immune defense against cancer.

Dr. Shiuan Chen, a senior author of the study, stated that foods like white button mushrooms, along with other plant-derived substances, may support traditional cancer treatments. This could pave the way for integrating food-based therapies into standard cancer care.

In animal models, white button mushroom extract significantly delayed tumor growth and improved immune responses. The trial also involved blood samples from men taking mushroom supplements, showing a promising decline in tumor-promoting cells after three months of treatment.

Dr. Xiaoqiang Wang emphasized the importance of professional guidance when considering dietary supplements, as not all products on the market are FDA-approved. However, he suggested that adding fresh white button mushrooms to one’s diet may be beneficial.

For those interested, City of Hope is conducting a clinical trial funded by the National Cancer Institute. This research is focused on the impacts of mushroom treatment on prostate cancer outcomes.

The study is detailed in the October 10, 2024 issue of Clinical and Translational Medicine. The research received support from the National Institutes of Health and the Panda Charitable Foundation.