Cancer Cells from Blood Could Help Tailor Breast Cancer Treatment
Blood Test May Reduce Over-Treatment of Early-Stage Breast Cancer
at a Glance:
* What: Researchers developed a “labyrinth chip” to detect circulating cancer cells in blood samples,potentially allowing for more personalized breast cancer treatment.
* Where: University of Michigan and University of Kansas Medical Center.
* When: Research published in Science Advances (2023). The labyrinth chip was launched in 2017.
* Why it Matters: Currently, all women diagnosed with early-stage (DCIS) breast cancer receive treatment (surgery, radiation, hormone therapy) due to the inability to predict which cancers will become invasive. this test could identify patients who don’t need aggressive treatment, sparing them unnecessary side effects and improving quality of life.
* What’s Next: Further research and clinical trials are needed to validate the biomarkers identified and implement the test into standard clinical practice.
Key Facts:
* Approximately 2.3 million women are currently living with breast cancer.
* Around 25% of diagnoses are DCIS (ductal carcinoma in situ) – early-stage, non-invasive cancer.
* 10-53% of untreated DCIS cases become invasive.
* 10% of patients treated with surgery alone experience cancer recurrence within 10 years.
* The “labyrinth chip” separates cancer cells from blood samples,enabling diagnostic testing even with very small quantities of cells.
* The goal is to identify biomarkers that predict cancer progression and guide treatment decisions.
Data Summary:
| Cancer Stage | Prevalence | Invasive Risk (Untreated) | Recurrence Risk (Surgery Alone) |
|---|---|---|---|
| DCIS | ~25% of breast cancer diagnoses | 10-53% | ~10% within 10 years |
