Boramae Hospital Prof. Ji-Young Lee’s team, “Male, up to 1.2 times higher confirmed”
[현대건강신문] As a result of analysis by Korean medical staff, cholecystectomy was found to increase the risk of developing Parkinson’s disease.
Cholecystectomy refers to surgery to remove the gallbladder with an invasive tool to solve diseases occurring in the gallbladder.
A joint research team led by Professor Ji-Young Lee of Neurology at Seoul Boramae Hospital and Professor Cheol-Min Shin of Gastroenterology at Seoul National University Bundang Hospital recently announced the results of a study stating that cholecystectomy, which is performed to treat various diseases occurring in the gallbladder, may increase the risk of developing Parkinson’s disease in the future. did.
Parkinson’s disease is a disease that causes major disturbances in daily life due to degeneration of cranial nerve cells, which causes movement disorders such as rigidity (hardening), dyskinesia (slow movement) and tremor, and gradually progresses to a gait disorder. In modern society, the incidence rate is continuously increasing.
Recently, a joint research team led by Professor Jiyoung Lee of Neurology Department at Boramae Hospital and Professor Cheolmin Shin of Department of Gastroenterology at Seoul National University Bundang Hospital used an anonymized database of the National Health Insurance Corporation and worked with Dr. The risk of developing Parkinson’s disease due to cholecystectomy was studied by comparing and analyzing 1,838 patients and 296,135 patients who did not undergo cholecystectomy.
As a result of analyzing various risk factors for developing Parkinson’s disease, it was confirmed that the risk of developing Parkinson’s disease due to cholecystectomy increased by 1.14 times.
In particular, in men, the risk increased by up to 1.2 times, whereas in women, no statistical significance was found, so the research team determined that cholecystectomy in men could increase the risk of subsequent Parkinson’s disease.
Professor Lee Ji-young said, “As this study is an epidemiological study using big data, there is a limitation in not being able to suggest a pathophysiological mechanism between cholecystectomy and the onset of Parkinson’s disease. It is highly suggestive in that it suggested the possibility of a negative effect on the risk factor and that the increase in absolute risk was not large, but a significant effect was confirmed even after adjusting for various risk factors.”
Professor Shin Cheol-min said, “Bile is known to have a great effect on the composition of intestinal microbes. When the gallbladder is removed through surgery, the metabolic process of bile is changed, and the composition of bile acids and the bile circulation pool in the human body are greatly changed. As a result, changes in the microflora in the intestinal tract can occur, leading to disturbance of the homeostasis of the intestinal microflora-gut-brain axis. There is a possibility that degeneration also has a negative effect, so mechanistic studies and clinical studies to prove this hypothesis need to be expanded in the future.”
Meanwhile, the results of this study were published in the latest online edition of ‘NPJ Parkinson’s Disease’, an international academic journal published by ‘Springer Nature’.
