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Lilly’s Obesity Drug Shows Dramatic Weight Loss, But Discontinuation Rates High – Biotech Readout
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Good morning. the obesity data keeps coming this week. We’ll get straight into it.
The Need-to-Know This Morning
- Resolution said its experimental drug failed to reduce episodes of low blood sugar in patients with congenital hyperinsulinism, missing the efficacy goal of a Phase 3 trial.
- AC Immune said its immunotherapy showed the potential to slow the progression of Parkinson’s disease, based on preliminary results from a mid-stage study.
- Rhythm Pharma announced preliminary study data showing its drug could reduce hunger cravings and lower the BMI of people with Prader-Willi Syndrome.
- Geron announced a corporate restructuring including a one-third reduction in its workforce.
Lilly’s Triple-G Drug Leads to major Weight Loss, But With Many Discontinuations
Eli Lilly’s next-generation obesity drug led to what appears to be the most weight loss seen so far in a late-stage trial, but rates of side effects were high and many participants discontinued the treatment, including people who felt they were losing too much weight.
At a glance
- Drug: Lilly’s triple-G drug (exact name not specified in source)
- Indication: Obesity
- Trial Phase: Phase 3
- Key Finding: Significant weight loss observed.
- Concern: High discontinuation rate due to side effects and perceived excessive weight loss.
- What’s Next: Further analysis of trial data, potential regulatory submissions.
The drug, which combines tirzepatide with two other undisclosed compounds (hence “triple-G”), demonstrated an average weight loss of[**Insert Specific Percentage/Weight Here
