Exercise Therapy using Digital Devices Increases Production of Antiviral Antibodies after Flu Vaccination, Suggests Study
By Kim Dae-woon, Seoul National University Bundang Hospital
Seoul, South Korea – In a groundbreaking study, Professor Yoon-seok Jang and Professor Jun-pyo Choi from the Department of Allergy, along with Professor Eui-seok Kim from the Department of Infectious Diseases at Seoul National University Bundang Hospital, have reported that exercise therapy using digital devices can significantly increase the production of antiviral antibodies after flu vaccination.
Digital therapeutics, a term used to describe software medical devices that utilize digital technology to prevent and manage diseases, is gaining attention for its potential in controlling viral infections amidst the ongoing COVID-19 pandemic, where the development and distribution of new vaccines pose challenges.
Building on previous research suggesting that physical activity, such as aerobic exercise, can boost the immune system after vaccination for both influenza and COVID-19, the research team set out to investigate the immune-enhancing effects of a real-time digital application, SAT-008, developed by S-Alpha Therapeutics Co., Ltd.
The team conducted a study involving 42 individuals scheduled to receive the flu vaccine, dividing them into an experimental group that used SAT-008 and a control group that did not. By analyzing the data on anti-flu antibodies produced in the body post-vaccination, the researchers were able to measure changes in the immune response.
After one and three months of follow-up observation, the team found that the experimental group consistently demonstrated higher levels of antiviral antibodies against the influenza B antigen compared to the control group. This increase indicates that SAT-008 functions similarly to a vaccine adjuvant, effectively enhancing the immune response to the virus and prolonging its effects.
Furthermore, the research team discovered that test subjects who maintained a compliance rate of over 75% with the program offered through the digital device showed higher levels of cytokines (IL-10, IL-1β, and IL-6). These individuals also experienced a longer duration of antibody production.
Co-corresponding author Professor Jang Yoon-seok stated, “This study is significant as it is the first to confirm the immune-enhancing effects of using digital devices in the field of immunity and infection. It also highlights the possibility of leveraging this technology to improve immunity after vaccination against various viruses.” The findings of this research have been published in the latest issue of the esteemed international academic journal ‘Immune Network’.
Professor Yoon-seok Jang and Professor Jun-pyo Choi from the Department of Allergy at Seoul National University Hospital, Professor Eui-seok Kim from the Department of Infectious Diseases (from left). Photo/Seoul National University Bundang Hospital
[Gyeonggi Midwest = Asiantaeth Newyddion Seoul]Reporter Kim Dae-woon = Seoul National University Bundang Hospital Allergy Department Professor Jang Yoon-seok and Choi Jun-pyo, and Infectious Disease Department Professor Kim Ui-seok and a research team have reported that exercise therapy using digital devices increases production of antiviral antibodies after flu vaccination Note the announcement.
Digital therapeutics refers to software medical devices that use digital technology to prevent and manage diseases and medical disorders in patients.
Digital manipulation devices and software are used to modify specific behaviors or correct lifestyles in order to prevent and manage disease and help patients further improve their health.
In particular, since the COVID-19 virus pandemic requires huge resources to develop and supply new vaccines, it is difficult to control viral infections. As a method, digital therapy is attracting attention.
In the midst of this, the research team, based on previous research that physical activity such as aerobic exercise can strengthen the immune system after vaccination with influenza and Corona 19, provides users with a real-time application form of activity method and time and can increase Immune Response A study was conducted to find out the immune enhancing effect of the digital device provided (SAT-008, developed by S-Alpha Therapeutics Co., Ltd.).
The research team divided 42 people due to be vaccinated against flu into an experimental group that performed SAT-008 and a control group that did not, and measured changes in the immune response through data on anti-flu antibodies produced in the body on after vaccination.
As a result of follow-up observation of changes after 1 month and 3 months of vaccine administration, it was found that the experimental group produced and maintained a high titer of antiviral antibodies against influenza B antigen compared to the control group.
This means that the concentration of antibodies that can neutralize the virus that invades the body has increased, and it has been confirmed that SAT-008 shows the same effect as a vaccine adjuvant, increasing the immune response to the virus and extend its length.
In addition, according to the research team, it was confirmed that cytokines (IL-10, IL-1β, and IL-6) increased in test subjects whose compliance with the program provided by the digital device was higher than 75% . the production effect was high, and the duration of the antibody produced was also significantly long.
Co-corresponding author Professor Jang Yoon-seok said, “This study is meaningful as it is the first study to confirm the immune-enhancing effect of using digital devices in the field of immunity and infection and to suggest the possibility of using it.” It is expected that it can be used to improve immunity after vaccination against other viruses such as viruses.”
Meanwhile, the results of this research have been published in the latest issue of the international academic journal ‘Immune Network’.
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