[Facilmente frainteso]Does long-term high-dose vitamin D supplementation in older adults increase the risk of dementia? Doctors explain relevant research in detail – HakkaNews
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You can first know:
(1) Mice with Alzheimer’s disease become more severely ill if fed sufficient vitamin D, but this can only be interpreted as “eating more vitamin D when you are sick is harmful”, not “eating more vitamin D when you are not is sick” will be harmful” Sick”.
(2) This study was an experiment on mice, and animal experiments do not mean that the results will be the same in humans.
(3) The health insurance database search uses the “active vitamin D” group which is a “drug”, not the “inactive vitamin D” which the general public buys and eats and is a “nutritional supplement”.
(4) Most people who use active vitamin D are kidney patients. Renal patients are inherently a high-risk group for dementia. This data analysis should be “correlated” rather than “causal.”
The post “The more vitamin D you eat, the more brain cells might die?!” was posted on the Internet, mentioning animal experiments on Alzheimer’s disease and noting that vitamin D supplementation will worsen the condition, and an analysis of Taiwan’s health insurance database also showed the same result. However, experts said that animal experiments do not mean the same is true for humans, and the health insurance database analyzed “active vitamin D” for medicinal purposes, not “inactive vitamin D” which ordinary people take them as food supplements.
Will taking vitamin D cause dementia?
Original version rumored:
National Institutes of Health research: Long-term high-dose vitamin D supplementation in older adults may increase dementia risk instead of reducing it
And disseminate relevant content on social and news platforms:
Explanation of the verification:
Rumors stated that “in animal experiments on Alzheimer’s disease, it was observed that vitamin D supplementation can significantly ‘accelerate’ the death of brain nerve cells and aggravate the deterioration of cognitive function.” “Vitamin D supplementation aggravates the progression of Alzheimer’s disease: animal model and human cohort studies,” published in the academic journal “Aging Cell” in March.
In the same period, the Ministry of Health and Welfare also held a press conference in which it was explained that the study was divided into two parts: in the first part, the research group carried out experiments on mice and discovered that, under conditions of feeding sufficient amounts of vitamin D, children with Alzheimer’s disease In contrast, blood levels of vitamin D in mice were low, but the amount of vitamin D receptor protein in the brain increased rather than decreased and was found together with senile amyloid plaques in the brain causing neuropathy.
In the second part, after obtaining the above experimental results, the research team used Taiwan’s health insurance database to conduct the analysis, and found that if elderly people who do not suffer from dementia take “active vitamin D3 ” (calcitriol) every year, the risk of developing dementia is The risk of death is 1.8 times higher than that of non-users; if the person suffers from dementia, the risk of death is 2.17 times higher than that of non-users. These figures are the main content of the entries.
(1) Animal testing is not the same as the human body
MyGoPen consulted Fu Zhongling, deputy director of the Taipei Wing General Neurological Center and executive director of the Taiwan Clinical Dementia Society, who said that the first part of the study used mice with Alzheimer’s disease, so it should be interpreted as having Alzheimer’s disease. Alzheimer’s. It is harmful to eat too much vitamin D if you have Alzheimer’s disease, but you will get the disease if you eat vitamin D if you are not sick. However, Alzheimer’s disease lurks in the brain for 20 years before Alzheimer’s disease appears .Amyloid-free After the exam, people will not know whether they have pathological changes. Clinical advice is that if there are no memory problems at the moment, it is not advisable to take the test until symptoms appear. Fu Zhongling pointed out that it is not scientifically certain whether the results of general animal experiments can be applied to humans, so good research will combine animal experiments and human clinical reports to win people’s trust.
(2) The investigational drug is not commercially available vitamin D.
Fu Zhongling pointed out that the data used by the research is to prescribe “active vitamin D3” in health insurance information. It is different from the “inactive vitamin D3” that ordinary people buy and eat. Conditions for prescribing active vitamin D3 in health insurance include: vitamin D-dependent rickets, hypophosphatemic rickets; hypoparathyroidism; hypocalcemia caused by chronic renal failure; Postmenopausal women suffering from compression fractures of the spine or hip fractures, etc.
(3) The same groups taking medications in the health insurance database are at high risk for dementia.
Fu Zhongling pointed out that for vertebral or hip compression fractures, because other osteoporosis drugs cannot be used together, active vitamin D3 is rarely prescribed as the main drug for treatment when other osteoporosis drugs are more effective than active vitamin D3. Therefore, the active group of vitamin D3 in health insurance not only has some pathological states, but many are also used due to poor kidney function. However, in medicine it is known that patients with poor kidney function have a higher incidence of dementia. The rate of chronic kidney disease and dementia exceeds 30% and it can be said that the worse the kidney function, the higher the rate of dementia. Fu Zhongling said that when the National Institute of Health published this study, it caused controversy. Many experts believe the National Institutes of Health study showed a “correlation” rather than an inevitable “causal relationship.” Fu Zhongling pointed out: “I also agree with the above view.”
Fu Zhongling appealed to the fact that causal research is very difficult. Most studies are correlational studies, so conclusions usually need to be written more conservatively. However, some studies are exaggerated in the public communication process and are easily misleading. The public receives relevant information. When spreading rumors, you should carefully read the content or search for published, credible information to compare and clarify.
In short
The research mentioned in the entry is divided into two parts: mouse experiment and health insurance database analysis. The mouse experiment is the result of administering vitamin D to already sick mice. Therefore, the conclusion should be interpreted to mean that mice that are already sick should eat more vitamin D. It is harmful, not healthy, for people to get sick if they take vitamins, but the reality is that most people do not know about have Alzheimer’s disease until you develop symptoms. The research should contribute to increasingly important advances in the future. There is progress, but there is a gap with practical value for people. There is no need for people to misinterpret it or panic unduly.
The second part of the study was to analyze the health insurance database, but the data obtained was for the use of “active vitamin D3”, but the general public takes “inactive vitamin D3” (cholecalciferol). Active vitamin D3 is a drug, and inactive vitamin D3 is dietary supplements, what people get from diet, health food, or sun exposure is “inactive vitamin D3”. Experts also said that most of the active users of vitamin D3 in health insurance are kidney disease patients. Kidney disease patients themselves constitute a high-risk group for dementia. This study is a “correlation” study, not a “causality” conclusion.
Health education resources:
Ministry of Health and Welfare – Is vitamin D a double-edged sword? National Institute of Health finds long-term use of vitamin D3 in older adults may increase risk of dementia
Health 2.0 – Does vitamin D3 increase the risk of dementia? Active and inactive structures are different! If you can’t tell the difference, just look at the “unity”
Ask the experts:
Deputy Director of Taipei Wing General Neurological Center – Fu Zhongling
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