Six serum peptides have been used as biomarkers… Currently, diagnosis is made by x-ray.
Posted on 04.28.2024 18:10 Posted on 04.28.2024 18:10 Modified on 04.28.2024 11:13 Views 1
Predicting knee osteoarthritis 8 years in advance can be of great help in slowing down its progression. Early diagnosis is possible with a blood test. [사진= 게티이미지뱅크]Knee osteoarthritis is diagnosed based on the results of an x-ray test (radiation test). However, at the time of diagnosis, knee osteoarthritis has already progressed significantly. Treatment to relieve symptoms is not easy.
Research has shown that knee osteoarthritis can be diagnosed early with a blood test, eight years before it is diagnosed with an x-ray. A research team from the Duke University School of Medicine in the United States has announced that it has developed, following a clinical study on 200 women, a test to predict the onset of knee osteoarthritis eight years later using six specific proteins (serum peptides).
According to the research results, the diagnostic accuracy (AUC, area under the curve) for predicting knee osteoarthritis using six specific proteins as serum biomarkers was found to be approximately 77%. This is much more accurate than the previous two predictive tests. The diagnostic accuracy of predictions based on age and body mass index (BMI, units kg/㎡) is approximately 51%, and the diagnostic accuracy of predictions based on knee pain is approximately 57%.
“We have developed a blood test that is significantly better than current diagnostic tools that do not identify knee osteoarthritis until it has caused significant damage to the joint,” said senior author Professor Virginia Byers Krause (Orthopaedics and Pathology). of study.
The study results also showed that of the 24 protein biomarkers that can be used to predict the development of knee osteoarthritis, the majority (58%) were useful in predicting disease progression.
Osteoarthritis is the most common form of arthritis. According to the research team, approximately 35 million adults in the United States suffer from it. This corresponds to approximately 10.2% of the total population. If we only consider adults, the prevalence rate is much higher. An estimated 4 million people in Korea suffer from this degenerative disease. There is no definitive cure yet and only the symptoms can be alleviated. Therefore, detecting this disease early and slowing its progression can be of great help.
Professor Krauss said: “With a blood test, we can detect knee osteoarthritis much earlier than with the current X-ray method. “If diagnosed using current X-ray tests, the disease is already quite advanced, making difficult to treat,” he said. He said: “Blood biomarker testing developed prior to this showed 74% accuracy in predicting the progression of knee osteoarthritis and 85% accuracy in diagnosing knee osteoarthritis.”
The research team used a large database in the United Kingdom. Half of the participants were diagnosed with knee osteoarthritis and the other half did not have the disease. The team analyzed the serum and detected molecular traces of knee osteoarthritis in many of the women who had been diagnosed eight years earlier via X-rays.
The results of this study (An osteoarthritis pathophysiological continuum revealed by molecular biomarkers) were published in the international journal Science Advances.
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