The Catholic College University of Medicine declared on the 24th that Professor Jeon Heung-jae from the Office of Biomedical Sciences and Professor Yang Dae-hyuk from the Cell and Tissue Engineering Study Institute have made a new 3D bioprinting material and process that does not n hurt transplanted cells. .
3D printing has lately been highlighted in the industry of stem cell regenerative medicine in that it can design and style and manufacture cells and scaffolds for transplantation in accordance to the shape and size of the lesion, so named individual customization.
Distinct products are employed for bio-ink, which is a raw material for printing, but among them, hydrogel gets the most consideration because it has the construction most related to dwelling tissue. Nonetheless, UV light-weight is utilised in the procedure of curing the h2o-soluble sol to kind a 3-dimensional construction, which has a important trouble as it inevitably damages ink-printed stem cells due to the character of light UV.
In buy to solve this difficulty, Professor Heungjae Jeon’s study crew tried to acquire a product that can be healed in the visible light area in its place of ultraviolet mild. Amid organic products and solutions, chitosan, which has fantastic prospective as a biomaterial, but is limited in its use because of to its bad solubility, was released to an organic synthesis system to establish a drinking water-soluble 3D printing ink. We have made a 3D bioprinting method that it damages aged cells.
The chitosan selected by the study group is a all-natural solution with the widest selection of programs as a biomaterial, but has not been used as a bio-ink owing to its small drinking water solubility.
On the other hand, ‘chitosan glycol methacrylate (MeGC)’ is made when the h2o-soluble chitosan glycol polymer (GC) produced by introducing a glycol group to chitosan passes by methacrylate, thus, it was regarded as that the chance if made use of large more than enough.
In buy to verify this speculation, many factors these as printability (stacking ability), protein adsorption, mobile viability, and MeGC mobile proliferation were being analyzed. In distinct, MeGC-70, fashioned by photocuring 3% of the precursor alternative for 70 seconds, was discovered to remarkably increase bone differentiation in comparison to bioinks below other problems.
Through this, the investigation crew produced a mild-curable 3D bioprinting system that does not destruction the transplanted cells at all, and instructed the likelihood of its application as a extensive tissue engineering and regenerative drugs platform.
On the other hand, this study is the most prestigious global tutorial journal in the entire world, first in the JCI ranking in the area of organic chemistry (Rank by JCI, Chemistry, Organic 1/63). [Carbohydrate Polymers (IF=10.723)]published on July 1st.
Professor Jeon Heung-jae mentioned, “I am extremely proud to be able to reach great outcomes in exploration carried out with the support of the Ministry of Trade, Sector and Power (strategic main substance technological know-how improvement challenge) which is being promoted,” he stated.
