(37) Schizophrenia-vomiting-hiccup treatment ‘haloperidol’
The COVID-19 pandemic awakens the importance of medicines such as vaccines to prevent infectious diseases more than ever. In particular, it focuses its efforts on increasing the self-sufficiency rate for essential medicines to protect the lives of its citizens.
In this regard, this paper will continue to review essential national medicines in order to remind ourselves of medicines that are indispensable to the country. Following the first series of ‘Essential Medicines to Protect’ on March 15 last year, this is the 37th time to investigate ‘Haloperidol’, a treatment for schizophrenia.
First of all, schizophrenia is a term that was changed from schizophrenia (disease) in 2011 because there is a sense of social alienation or rejection. Here, chohyeon means choosing the strings of a stringed instrument, and is derived from the fact that schizophrenic patients are like a confused figure whose stringed instruments are not normally tuned.
The cause of schizophrenia is still unknown. However, it is known to be a biological disease caused by abnormalities in the brain, and is caused by a combination of biological, genetic, stress and shock.
Typical symptoms are hallucinations and delusions, disorganized language and behavior, catatonic behavior, apathy, and negative symptoms, and there are symptoms caused by emotional expression, motivation, and interpersonal relationships.
Treatment is based on drug treatment, and initially, risperidone is administered, and treatment is used selectively depending on the patient’s condition. Schizophrenia medications are psychotropic drugs that reduce patients’ delusions, hallucinations, anxiety and tension.
Treatments include Furuangsol, Purinal, Zyprexa, Ciroquel, Risperdal, Clozalil, Haloperidol, Sulfiride, Thiodazine, Chlorpromazine, Bromperidol, Pimozit, Nevus, Neponide, Perphenazine, Rhodopine etc.
Among them, haloperidol is also used for Tourette syndrome. Tourette Syndrome is a neurological disorder characterized by repetitive involuntary movements and sounds. Motor tics such as eye blinking, eye rolling, shoulder shrugging, head tilting, sudden force on the abdominal muscles, leg kicks, and vocal tics such as coughing and sniffling for more than a year.
On the other hand, Tourette syndrome, which has a large genetic influence, is accompanied by attention deficit hyperactivity disorder, obsessive-compulsive disorder, sleep disorder, emotional disorder, and behavioral disorder, as well as tics, and there are three times more common in males than females.
Here, three domestic pharmaceutical companies, including Whanin Pharmaceutical, Myeongin Pharmaceutical, and Janssen, have received approval from the Ministry of Food and Drug Safety for haloperidol preparations, and a total of 13 products are being supplied.
▶ Peridol Tablet 1.5mgis a haloperidol drug approved by Whanin Pharmaceuticals in 1981. It is used for schizophrenia (schizophrenia), manic episodes associated with bipolar disorder type 1, symptoms of psychotic disorders, Gilles de la Tourette syndrome, vomiting, and hiccups .
For adults and children over 14 years of age, schizophrenia (schizophrenia), manic episodes associated with bipolar disorder type 1, symptoms of psychotic disorders, and Tourette syndrome (Gilles de la Tourette syndrome) are treated with an initial dose of 1 -15 mg per day Oral administration in 2 to 3 divided doses (up to 100 mg may be given in severe cases). When a therapeutic response is achieved, the dose is gradually reduced to the minimum effective maintenance dose.
It increases or decreases appropriately according to age and symptoms, and for the elderly and debilitated patients, the initial dose of 1 to 6 mg per day should be given orally in 2 to 3 divided doses. For vomiting, 2 to 3 mg per day is given orally in two divided doses, and for hiccups, 4.5 mg per day is given orally in three divided doses, and the dose is adjust according to the treatment response.
The drug produced earned 156.72 million in 2019, earned 154.44 million in 2020 and 2021, and earned 154.92 million in 2021. Peridol Tablets 5 mgDuring the same period, it earned 298.91 million to 294.04 million, earned 295.64 million, was licensed in 1983 and contracted to manufacture by Shin Poong Pharmaceutical painfulsupply 117 million won and 117.25 million of 146.4 million won in 2019.
Also licensed in 1984 Peridol Tablets 10mgIt produced 308.14 million won in 2019, 307.4 million won in 2020, and 308.25 million in 2021. licensed in 1985 Peridol 3 mgsupply 154.69 million won in 2019, 112.269 million won the following year, and 153.41 million won in 2021. Licensed in 1989 Peridol Tablets 20mgIn 2019, 121.69 million won, 2020 and 2021, 119.14 million were produced and supplied consecutively.
▶ Haloperidol Myeongin Tab 1.5mgis a haloperidol drug approved by Myungin Pharmaceuticals in 1985, four years later than Whanin Pharmaceuticals. This is the point at which Myungin Pharm drew attention to the drug.
In the case of the psychotropic drug, the mortality rate is relatively high, and the risk of adverse reactions from cerebrovascular disease increases and the risk of venous thrombosis increases.
Accordingly, patients in a coma, alcoholics, patients under the strong influence of central nervous system depressants such as barbiturates or anaesthetics, patients with severe heart failure, Parkinson’s disease, Lewy body dementia, patients with progressive supranuclear ophthalmoplegia, patients with broncho-pneumonia, etc. it should not be administered
After producing 116.614 million won in 2019, the drug supplied 178.73 million won in 2020 and 180.86 million won in 2021 to the market. licensed in 1985 Myeongin Haloperidol TabletDuring the same period, the production performance of 256.96 million won, 257.46 million won, and 258.34 million won, Myungin Haloperidol Tablets 5mgDuring the same period, 326.55 million won, 245.95 million won, and 244.9 million won supplied. Myeongin Haloperidol Tablets 3mgwas approved in 1985 and decreased slightly to 155.39 million won in 2019, 125.34 million in 2020, and 92.58 million in 2021.
Then, in 1987, he was licensed Myeongin Haloperidol Injection132.04 million won in 2019, 106 million won in 2020, 130.42 million won in 2021, most recently approved in 1989 Myeongin Haloperidol Tablets 20mg247.4 million won were generated in 2019, 124.29 million won in 2020, and 249 million won in 2021.
▶Haldoldecanoas Injectionis a haloperidol decanoate formulation approved by Janssen Korea in 1993. The ingredient is haloperidol, 50 milligrams.
It is used for maintenance therapy for psychosis and for chronic psychotic patients who require long-term anti-psychotic medications. To prevent the possibility of unexpected adverse reactions to haloperidol, this drug must be stabilized with oral haloperidol before administration of this drug.
After importing $33,033 in Korea in 2019, the drug recorded imports of $28,460 in 2020 and $28,698 in 2021.
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