[의학신문·일간보사=이상만 기자] Among the national cancer screening programs in Korea, the colorectal cancer screening program includes a stool occult blood test that detects colorectal cancer at an early stage through the presence or absence of blood components in the stool and the presence or absence of bleeding.. However, despite positive findings in the fecal occult blood test, there are many cases in which no bleeding is detected in colonoscopy, which is related to immune diseases..
Choong-Kyun Noh, Professor, Department of Gastroenterology, Ajou University Hospital(Professor Beom-hee Park, Department of Medical Information·Eunyoung Lee Researcher)A research team led by Professor Ahn Seong-soo of the Department of Rheumatology at Yongin Severance Hospital announced the results of a study that showed a relationship between fecal occult blood and rheumatoid arthritis, a systemic inflammatory disease..
The research team used national cancer screening data from the National Health Insurance Corporation. 2009from year 2013by year 5Drugs that have been screened for colorectal cancer in years 900Out of 10,000 subjects, considering age and gender 160According to the fecal immunochemical test results of 10,000 people, the analysis was divided into positive and negative.. In the case of the positive patient group, additionally, those with bleeding confirmed by colonoscopy(colorectal cancer, inflammatory bowel disease, hemorrhoids, etc.)was excluded.
two groups(positivity, voice)second 2019year 12about by month 8Rheumatoid arthritis among immune-mediated inflammatory diseases, systemic lupus erythematosus, The incidence and risk factors of psoriatic arthritis were analyzed..
As a result, the subject 1,044,955hit △ rheumatoid arthritis 7,645number of people(incidence rate 9.5number of people/1ten thousand years(person-years, 1per ten thousand 1Number of occurrences when observed in years)) △ lupus 208number of people(0.26number of people/1ten thousand years) △ psoriatic arthritis 101number of people(0.13number of people/1ten thousand years)confirmed this new occurrence.
For rheumatoid arthritis, the most common 1per million people year 9.5Although the number is small due to the occurrence of, The incidence of rheumatism in the general population of Korea 1per million people year 1.7-4.2compared to people 2more than twice the number.
Looking more closely, Rheumatoid Arthritis Tracked 1Most confirmed in the year, women than men 2more than double. Also, if the stool immunochemical test result is positive, risk compared to voice 16% was higher, △ female △ 70under the age of △ low high-density cholesterol(HDL) increased risk in the group.
Although it is difficult for the research team to explain the occurrence of immune-mediated inflammatory diseases by direct causal relationship,, He said that it is meaningful in that it was based on large-scale data from the national cancer screening program..
Professor Noh Choong-gyun “In this study, we confirmed the possibility that stool immunochemical testing, which is mainly performed for early diagnosis of colorectal cancer, can be used for early detection of immune-mediated inflammatory diseases such as rheumatoid arthritis, which have a complex developmental mechanism.”saying “If you have symptoms or risk factors that suggest rheumatoid arthritis when abnormal stool immunochemical tests are found, you can seek medical attention early.”said.
In addition “It is hoped that fecal immunochemical testing will contribute to broadening the range of diagnostic possibilities, such as early detection of immune-mediated inflammatory diseases such as rheumatoid arthritis, or improving predictability.”added.
On the other hand, the results of this study 2022year 7World’s leading magazine in the field of medicine BMC medicine(IF 11.150)to ‘A positive faecal immunochemical test result and its association with the incidence of rheumatoid arthritis, systemic lupus erythematosus, and psoriatic arthritis: an analysis of one-million national colorectal cancer screening programme results(Positive stool immunochemical test and rheumatoid arthritis, systemic lupus erythematosus, Relationship with the incidence of spondyloarthritis)‘published under the title.
