Medical Genome Center Ramathibodi Hospital Whole genome sequencing (Whole SARS-CoV-2 genome sequencing) and genotype (MassARRAY Genotyping) were decoded over two years to examine the 2019 coronavirus strains and mutations to assess efficacy and modification. “Antiviral” and “monoclonal antibody” for precision medicine in accordance with the subspecies of omicron the patient is infected with.
from decoding genetic specimens from various hospitals in Bangkok And perimeter in the past 30 days, 100 samples found subspecies of omicron.
BA.1 2.2 percent
BA.2* 13 percent
BA.4* percentage 54.3
BA.5* 26.1%
BA.2.12.1 4.3%
The omicron subspecies BA.5.3.1 and BA.2.75 have not yet been found.
Omicron BA.4 and BA.5 were found for the first time in South Africa. In January 2022, then it has spread all over the world.
The proportion of outbreaks of BA.4 and BA.5 in each country is different.
– South Africa found BA.4>BA.5 in a ratio of 4 to 1
– Portugal found BA.5>BA.4 in a ratio of 4 to 1
-United Kingdom, found BA.4>BA.5 in a ratio of 2.3 to 1
– USA found BA.4>BA.5 in a ratio of 1 to 1
*Thailand meet BA.4>BA.5 in proportion 4.4 continue 1 
From graphs 1-5, it can be seen that each country has a lower peak in the number of BA.4/BA.5 and BA.2.12.1 cases than that of BA.1/BA.2. different from Thailand The number of infected BA.4 is now higher than the BA.1 and BA.2 outbreaks in the past.
BA.4 outbreaks in Thailand in the past 2 months have a relative growth advantage of 157% compared to the current outbreak (BA.5).
BA.4 mutates differently from BA.5 in 7 positions.
BA.5 mutates differently from BA.4 by 1 position.
The thorn region BA.4 is mutated differently from BA.5 in 1 position.
There are not enough global clinical data for BA.4 and BA.5 to conclude that the two subspecies of omicron are pathogenic or “severity” (hospitalization or death). ) different?
#genome center
#Omicron subspecies
CR:Center for Medical Genomics
