High Cardiovascular Risk & LDL-C Goals: Challenges for Individuals
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The Problem: Patients with very high cardiovascular risk (CVR) need important reductions in LDL-C (low-density lipoprotein cholesterol) to prevent recurrent cardiovascular events, morbidity, and mortality.Dyslipidemia is a major modifiable risk factor.
The Issue: Despite the availability of effective lipid-lowering therapies (LLTs) like statins and PCSK9 inhibitors,LDL-C goal achievement rates are poor,especially in middle- and low-income countries.
The Study: The EDHIPO MARCA Registry in Colombia investigated LDL-C goal attainment in patients with very high CVR due to coronary artery disease (CAD) undergoing LLT, according to European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines. It was a retrospective, descriptive, multicenter analysis.
The Findings:
the study examined 1788 patients from 11 medical institutions in Colombia.
Statins were the most prescribed LLT (84.1% overall), with high-intensity statins used in 91% of cases. PCSK9 inhibitors were rarely used, and 4.7% of patients were discharged without any LLT.
* Only 36.6% of patients achieved LDL-C goals at their last follow-up visit.