High Genetic Risk and Clinical Risk Linked to Increased Incidence of Cardiovascular Diseases: Study

▲ Incidence of Cardiovascular Diseases by Genetic Risk and Clinical Risk (Photo = Provided by National Institute of Health, Korea Agency for Disease Control and Prevention)

[메디컬투데이=남연희 기자] As a result of clinical data, genetic information and 17 years of follow-up on Koreans, it was found that people at high clinical risk had a five-fold increase in the incidence of cardiovascular disease when the genetic risk was also high.

The National Institute of Health, Korea Agency for Disease Control and Prevention, announced on the 9th that it has improved the cardiovascular disease risk prediction method currently used for clinical diagnosis and published the results of a new one in the journal Cardiovascular disease risk prediction study tailored for Koreans. Frontiers of genetics.

Cardiovascular diseases, one of the top 10 causes of death in the world, are known to be a disease caused by a complex interaction between genetic factors from birth and various environmental factors such as age, smoking and lifestyle habits.

The American College of Cardiology has developed a tool to predict the risk of developing cardiovascular disease within 10 years using clinical information, allowing for early prevention, such as suggesting medications and improving lifestyle habits, for high-risk groups ( 10-year risk 7.5% or higher). It is recommended.

The National Institute of Health comprehensively assessed the risk of developing cardiovascular disease by analyzing clinical data, genetic information, and 17-year follow-up outcomes for 7,612 community cohorts during the Korea Genome Epidemiology Survey project.

Based on clinical risk calculated using only clinical data, people in the high-risk group were 3.6 times more likely to develop cardiovascular disease than the general population. However, even in people with a low clinical risk, the incidence of cardiovascular disease is increased approximately 1.5 times in those with a high genetic risk.

Notably, among people at high clinical risk, those at high genetic risk also had a 3.6- to 5-fold increase in the incidence of cardiovascular disease.

While previous studies used relatively short-term follow-up results, this study used 17 years of follow-up information and is significant in that it was able to increase the accuracy of cardiovascular disease prediction by integrating genetic information in clinical risk.

Park Hyun-young, director of the National Institute of Health, said: “Thanks to technological advances, the era in which individual genome information can be easily obtained, and early diagnosis and personalized treatment of many diseases is expected chronic diseases, including cardiovascular diseases, will be possible in the future based on big data “It will happen,” he said.

[ⓒ 메디컬투데이. 무단전재-재배포 금지]

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