Journalist Cho Min-gyu
awe0906@mdtoday.co.kr | 2024-05-10 07:58:58
▲ Research results have shown that a balanced diet and weight loss diet can improve the effectiveness of the vaccine. (Photo = DB)
[메디컬투데이=조민규 기자] Research results have shown that a balanced diet and weight loss diet can improve the effectiveness of the vaccine.
In a study conducted on obese mice, the results of a study demonstrating that a weight-loss diet can improve the effectiveness of the flu vaccine were published in “Nature Microbiology”.
The World Health Organization (WHO) has highlighted the importance of vaccines, saying that approximately 154 million lives have been saved through vaccination over the past 50 years. At the same time, however, he underlined that the effectiveness of the vaccine is not always as expected, due to various factors.
Vaccines have different mechanisms of action depending on the type, but they mainly work by awakening our immune system early by inserting proteins or genetic material of the target pathogen. Through vaccines, our immune system remembers information about the pathogen and is able to respond more quickly and effectively when subsequently infected with the actual pathogen.
Researchers have noted that obese people are at greater risk of contracting several infectious diseases, including influenza. While obesity itself can increase the risk of infection, researchers noted that obesity can also reduce the effectiveness of the flu vaccine.
The researchers took two groups of mice and fed one group a low-fat diet and the other group a high-fat diet. After all the mice were vaccinated, the diet of some mice on a high-fat diet was changed to the control diet. Next, the researchers gave the mice a lethal dose of the H1N1 influenza virus.
The study results showed that the survival rate of obese mice did not improve even when the diet was changed from a high-fat diet to a control diet. The survival rate of obese mice after 4 weeks was only 24%, and the survival rate of obese mice switched to the control diet was also only 28%.
The researchers added that this correlation could be explained by a T cell-driven immune response and suggests that certain diets and weight loss may help improve the effectiveness of the flu vaccine.
[ⓒ 메디컬투데이. 무단전재-재배포 금지]
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