A team led by Professors Seung-ho Yoo, Yu-soo Jang and Hye-sook Jeong of Sungkyunkwan University School of Medicine announced the results of research showing that women infected with the high-risk human papillomavirus (HPV) , which causes cervical cancer, are four times more likely to die from cardiovascular diseases such as heart disease and stroke than uninfected women.
This is the finding of the research team that combined and analyzed the HPV test results of 163,250 Korean women (average age 40.2 years) without cardiovascular disease and data on deaths due to cardiovascular disease.
HPV is a common sexually transmitted infection with an infection rate of 2-44% in the general female population, and high-risk HPV infection is known to cause cervical cancer.
When the research team combined data from HPV testing with national data on deaths from cardiovascular disease, including heart disease and stroke, they found that the risk of dying from cardiovascular disease was relatively low, at 9.1 per 100,000 people .
However, when other cardiovascular disease risk factors were excluded and the impact of high-risk HPV was analyzed, high-risk HPV infection was found to significantly increase cardiovascular disease mortality.
High-risk people with HPV infection have a cardiovascular disease (CVD) mortality rate of 7.1 per 100,000 person-years (a person-year is the value of observing a person for one year), which is 3.91 times higher than that of non-person-years. infected people (1.9) and mortality from ischemic heart disease (5.0). The stroke death rate (1.4 people) was 3.74 times higher and 5.86 times higher, respectively.
In a cohort study of Korean women, people infected with HR-HPV had a high mortality rate due to CVD (cardiovascular disease), especially ASCVD (atherosclerotic cardiovascular disease) and IHD (ischemic heart disease), which was more pronounced in obese people. Show trend – HR, hazard ratio for cardiovascular disease mortality; HR-HPV, high-risk HPV infection; CI, confidence interval; BMI, body mass index; CVD, cardiovascular disease. / Extract from the thesis
Additionally, obese women were found to be at greater risk if they were infected with high-risk HPV.
When body mass index (BMI) was 25 (kg/㎡) or higher, the risk of death from cardiovascular disease was 4.81 times higher for people infected with high-risk HPV than for uninfected people and for BMI less than 25. the risk for infected people was 2.86 times higher than for uninfected people.
The team said more research is needed to determine whether high-risk HPV infection has similar effects on men and whether the HPV vaccine can prevent death from heart disease.
Professor Jeong Hye-sook said: “Inflammation plays an important role in the development and progression of cardiovascular diseases, and viruses are known to be potential triggers of inflammation.” He added: “HPV in the bloodstream can cause inflammation in blood vessels, block and damage arteries and increase the risk of cardiovascular disease.” “You can,” he said.
“It is important that people with high-risk HPV infection are aware of their potential risk of heart disease and cervical cancer,” she said, “they should undergo regular health checkups and adopt a healthy lifestyle to mitigate the risk of disease cardiovascular. “
Professor Seungho Yoo said: “If the results of this study are verified, they could have a significant impact on public health strategies. Increasing HPV vaccination rates could be an important strategy to reduce the risk of disease long-term cardiovascular disease”.
The results of this study were published in the European Heart Journal, the journal of the European Society of Cardiology.
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