Researchers from the National Institute of Nuclear Technology (Public Organization) led by Dr. Sakchai Laksi, head of the team of inventors attended the hearing to receive a certificate of honor of the National Research Award Invention Award Fiscal Year 2024, excellent prize from the work titled “OhGold4Life: Smart nanocarriers as an emerging multifunctional gold nanohybrid technology platform for effective cancer therapy), which is an emerging nanohybrid technology platform. Gold works in many functions It is a smart nanocarrier for an efficient anticancer drug delivery system.
Associate Prof. Dr. Thawatchai Onchan, Director of the National Institute of Nuclear Technology (Public Organization) revealed that the research team of the National Institute of Nuclear Technology (Public Organization) or NSTDA has submitted an invention to participate in the National competition Research Award 2024 organized by the National Research Council of Thailand. It is the result of an invention by a team of DST researchers, with Dr. Sakchai Laksi, the head of the inventor’s team. Together with the team composed of Dr. Thitirat Rattanawongwiboon, Miss Pattra Lertsarawut, Dr. Kesinee Hemwichian, Dr. Thanakorn Sangthaweesin and Dr. Teeranant Taengthong, called “Oh Gold for Life” (OhGold4Life: Smart nanocarriers as an emerging technology platform of multifunctional gold nanohybrids for effective cancer therapy), which is a platform for the delivery system of anticancer drugs synthesized by nuclear technology. It is a simple and environmentally friendly process. This work was awarded a National Research Award. Invention Award Fiscal Year 2024 and previously OhGold4Life received the silver medal of International Innovation Award 2023 from Malaysia Technology Expo 2023, which is one of TST’s proud for demonstrating the benefits of using nuclear technology in care and maintenance of the health of Thai people
Dr Sakchai Laksi, leader of the OhGold4Life project, said cancer is a leading cause of death among many people around the world. Chemotherapy is one of the most popular cancer treatments with the use of anticancer drugs (anti-cancer drugs (ACDs)) to aid in treatment. However, this method has been found to have limitations due to its high toxicity to normal tissues. It causes extremely unwanted side effects. Therefore, many researchers are trying to solve this problem by delivering anticancer drugs using nanoscale drug delivery systems. Which is what stands out a lot. Gold nanohybrids (AuNH) lead to this invention, which is the development of smart nanocarriers as an emerging gold nanohybrid technology platform (OhGold4Life or Oh Gold Foam). OhGold4Life is a multifunctional anticancer drug delivery system synthesized using nuclear technology in a simple and environmentally friendly process. The particles are functionally modified with biopolymer derivatives in a systematic interaction that promotes the specificity of OhGold4Life against tumor cells. Increase the effectiveness of anticancer drugs and reduce side effects during use The experiment results demonstrated that OhGold4Life is capable of releasing the anticancer drug camptothecin (CPT) and increasing its ability to inhibit human lung cancer cells 2.82 times higher than CPT alone, while at the same time it is only toxic to normal human lung cells. . just a little This drug delivery system also shows specific cellular entry through folate receptor-mediated endocytosis and has high antitumor activity. It systematically stimulates tumor cell death by increasing tumor cell apoptosis by 13.97% and helps stop the growth of tumor cells in the G0-G1 phase of the cell cycle. According to these experimental results, Therefore, it is proven that the administration of Anti-cancer drugs uses OhGold4Life as one of these emerging platform technologies. This is a technology with potential that should be continuously developed as an effective anticancer drug delivery system. Helps treat and cure cancer This gives cancer patients more treatment options and also helps improve the quality of life of cancer patients.
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