Breakthrough in Anti-Aging Research: Wattanacheewa Extends Telomeres Length, Delays Cellular Aging
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Previously in 1977, Professor Pichet Wiriyachitra, Principal Investigator of Operation BIM and CEO of Asian Phytochemicals Public Company Limited or APCO, conducted groundbreaking research on the mangosteen fruit. Through his studies, Professor Pichet discovered the GM-1 extract of mangosteen, which exhibited remarkable properties in fighting bacteria and inflammation. Additionally, the extract showed a high antioxidant effect and demonstrated efficacy against cancer cells in laboratory tests.
With the aim of boosting the immune system, Professor Pichet further enhanced the extract by incorporating extracts from four other edible plants, including Centella asiatica, black sesame, soybean, and guava. This innovation proved to be effective in stimulating the immune system and improving the quality of life for cancer patients. In acknowledgment of this outstanding innovation, APCO received the prestigious Outstanding Innovation Award from the Stock Exchange of Thailand in 2016.
Commenting on the breakthrough, Professor Pichet stated, “These breakthroughs stimulate T cells or killer T cells to selectively target infected cells and cancerous cells without harming normal cells.”
A surprising discovery emerged from the follow-up of around 10,000 cancer patients who had used the original formula. It was found that their quality of life improved, including notable enhancements in skin health. This uncovered the potential of the formula not only in combating cancer cells but also in improving overall well-being. Treating or eliminating cancer cells while preserving normal cells is a key aspect of the formula’s mechanism.
Professor Pichet explained, “The innovation is believed to have an impact on the telomere at the end of the chromosome and facilitate its repair. This extract is developed from five types of plants that are commonly consumed, ensuring its safety.”
Five Plant Extracts for Aging Prevention
In subsequent research, Assoc Professor Preeya Leelahakul, an expert in anti-aging nutrition and a research consultant for APCO, conducted a study involving 10 participants who consumed Wattanacheewa for eight weeks. The study revealed that eight out of 10 participants experienced an increase in telomere length, resulting in a delay in cellular aging by up to 5.8 years. The participant with the highest increase in telomere length, a 53-year-old woman, demonstrated a 20% increase equivalent to 1,612 base pairs.
To validate these findings, blood samples were sent to a standard laboratory for analysis. The results highlighted improvements in various aspects of the participants’ health, including better skin, clearer complexion, and overall vitality. To further support these findings, the nutrition institute at Mahidol University is currently conducting a larger-scale study with 40-50 participants, with the results expected to be published soon.
APCO’s research team, Operation BIM, developed Wattanacheewa based on the original formula used for cancer patients. This extract, derived from five types of edible plants, successfully stimulates the enzyme telomerase in the body. Telomerase facilitates the repair and elongation of telomeres, thereby strengthening white blood cell function and bolstering the body’s immune system.
Professor Pichet emphasized, “The innovation works by stimulating the telomerase enzyme to repair and extend telomeres. However, the formula prioritizes the elimination of cancer cells without compromising telomere integrity.” The unique composition of Wattanachiwa, derived from the five plant sources, plays a crucial role in its positive effects on hematopoietic cell function.
Regarding the concern of telomere lengthening in normal cells potentially leading to the immortalization of cancer cells, Professor Pichet assured that Wattanacheewa was developed based on a formula previously used for cancer cell treatment. Extensive studies have shown that it increases telomere length while avoiding abnormal or cancerous cells.
“Watanchewa safely increases telomere length in normal cells by utilizing the extracts of five plant species. Consumption of Wattana Chiwa is effective at just 4-6 capsules per day, unlike alternative methods that would require consuming up to 1 kilogram or 2,000 capsules a day,” Professor Pichet explained. However, he cautioned against using Wattanacheewa for individuals with autoimmune diseases or other disorders that may disrupt immune system balance, suggesting they first address their underlying health concerns.
While Wattanacheewa primarily targets the elderly, there is also significant interest among younger age groups seeking to slow down the aging process. As such, APCO plans to develop formulas suitable for a wider audience.
Professor Pichet highlighted the significance of this innovation for healthcare and the understanding of the immune system and telomeres. He concluded, “Improving the health of older individuals contributes to the overall development of our nation and ensures a good quality of life.”
Understanding Telomeres and Human Aging
The human body consists of approximately 100 trillion cells. Within each cell’s nucleus, there are 23 pairs of chromosomes. At the end of each chromosome lies the telomere, which acts as a protective cap for the genetic unit or DNA. Telomeres are longest at birth and gradually shorten with age. On average, telomeres shorten by approximately 70 base pairs per year. However, certain lifestyle factors, such as an unhealthy diet, smoking, excessive alcohol consumption, sleep deprivation, and chronic stress, can accelerate telomere shortening by 200-300 base pairs per year.
During cell division, chromosomes divide, resulting in the shortening of telomeres. Consequently, the body’s regenerative processes decline, increasing the risk of various diseases. Telomerase, an enzyme, can counteract telomere shortening by extending their length. When telomeres lengthen, the aging process slows down.
In 2009, the Nobel Prize in Medicine was awarded to three American scientists, Elizabeth H. Blackburn, Carol W. Greider, and Jack W. Szostak, for their discovery of telomere protection and the enzyme telomerase, which facilitates telomere repair. This breakthrough has significantly contributed to anti-aging research.
Professor Preeya, an anti-aging nutrition expert, explained that telomeres naturally shorten as cells divide, leading to aging, senility, and the risk of degenerative diseases. Unhealthy behavior, such as excessive sugar consumption, smoking, alcohol consumption, lack of exercise, irregular sleep, and chronic stress, accelerates telomere shortening, with obese individuals experiencing faster telomere shortening than those of normal weight. Obesity is associated with various complications, including diabetes, high blood pressure, and elevated blood lipid levels.
“Telomere length is indicative of our future health. Slowing down telomere shortening or extending their length can prevent cellular deterioration,” emphasized Professor Preeya.
Various benefits arise from longer telomeres, such as a reduction in wrinkles, a more youthful appearance, a decreased risk of degenerative diseases, and improved sleep quality. Conversely, shorter telomeres lead to premature aging, wrinkles, aged skin, degenerative diseases, and sleep disorders.
Previously, around 1977 Professor Pichet Wiriyachitra, Principal Investigator of Operation BIM and CEO of Asian Phytochemicals Public Company Limited or APCO Conducted research studies on mangosteen, discovered GM-1 extract of mangosteen, which has excellent properties Very effective against bacteria It has a very high anti-inflammatory effect. Has a very high antioxidant effect and deals with cancer cells well in the laboratory
before enhancing the effect with extracts from 4 other edible plants, namely Centella asiatica, black sesame, soybean and guava until the innovation to strengthen the immune system Stimulating the body’s immune system to be more efficient. It has been used to help cancer patients and in 2016 received the Outstanding Innovation Award from the Stock Exchange of Thailand for caring for cancer patients for a better quality of life.
“These breakthroughs stimulate T cells or killer T cells to deal with problem cells. infected cells and cancerous cells without touching normal cells,” says Professor Pichet.
For Watanacheewa, Professor Pichet said it came from an unexpected follow-up to about 10,000 cancer patients who used an innovative formula that existed before. It was found that the quality of life improved better skin Therefore, there is no doubt that the product should not only deal with cancer cells. In addition to knowing that treating or killing cancer cells through killer T cells. to capture abnormal cells only do not touch normal cells
So it really aims. And it is safe because it was developed from 5 types of plants that are eaten in daily life, leading to the assumption that “The innovation is going to do something with the telomere at the end of the chromosome. and repair the body too.”
5 plant extracts to slow down aging
After that, Assoc Professor Preeya Leelahakul, an expert in anti-aging nutrition and the APCO research consultant studied to find that solution. A study was conducted on 10 users by taking Wattanacheewa for 8 weeks. They found that 8 out of 10 users had an increase in telomere length. Telomeres lengthened an average of 408 base pairs, delaying cellular aging by up to 5.8 years.
The highest extending user, at 1,612 base pairs, or a 20% increase, was a 53-year-old woman. The blood was drawn and sent to a standard laboratory that has been tested in this regard. Regarding the empirical results observed in the consumer sample, namely eating, sleeping, beautiful skin, clear face, and to reaffirm such results. nutrition institute Mahidol University has repeated the study. By increasing the number of users to 40-50 people, the results of the research are expected to be published soon.
Professor Pichet explained that APCO’s Operation BIM APCO research team had developed from the original formula previously used in cancer patients. Which is an extract of 5 types of edible plants that are well used to repair telomere successfully by stimulating the enzyme telomerase in the body that repairs telomeres making telomere longer and stimulating white blood cell function That is an important part of managing and destroy invading pathogens that destroy the body’s immune system.
“In our body there is telomerase. It will naturally repair and extend telomeres, but not much faster aging Culture innovation to stimulate this enzyme to be more. But if this enzyme alone is too much. The chance of getting cancer is very high. But for the culture formula, it kills cancerous cells first. There is no chance of damaging the telomeres,” says Professor Pichet.
The important difference between Wattanachiwa and others may also show these five plant components. Professor Pichet said that there are many important substances in every plant. If you use different extraction methods it will have different extracts It affects the hematopoietic cell function differently. which is a Wattanachiwa formula The research team has used the extraction method to obtain the desired active ingredients and used the amount of five active ingredients from the plant in the amount that has been investigated so far.
But what is of great concern in the science of increasing telomere length is that if there is an increase in telomere in normal cells then it will increase in cancer cells. Until making cancer cells immortal, but Wattanachewa, Professor Pichet said that Wattanalife was developed from a formula used to deal with cancer cells before and studies showed that it also increases telomere length.
“Watanchewa is therefore an innovation that safely increases telomere length from 5 plant species by adding it to normal cells. but not to abnormal cells or cancer cells. eating at a level that affects the body They found that we had to eat up to 1 kilogram or 2,000 capsules a day, whereas when eating Wattana Chiwa, only 4-6 capsules were consumed each day,” he said Professor Pichet.
However, Professor Pichet emphasized that Wattanacheewa developed from a formula that strengthens the body’s immunity, so patients with autoimmune diseases or other diseases that create discomfort for themselves should not use the Wattanachiwa formula. It should use the immune system to balance first
by Wattanachiwa’s main target group focusing on the elderly But people from other age groups also want to slow down ageing, and formulas will be developed for general groups as well.
“This is a new dimension in healthcare. and understand the mechanisms of the immune system and the role of the telomere. which is essential to have a good quality of life If can improve the health of those entering the elderly to stay strong. having good health makes the development of the country continue to grow,” said Professor Pichet.
Telomere and human aging
The human body is made up of counting cells. 100 trillion cells In the nucleus of each cell, there are 23 pairs of chromosomes. At the end of the chromosome is the telomere, or the cap. serves to protect the chromosomes which store the genetic unit or the DNA from being destroyed At birth, the telomeres are the longest and gradually decrease with age. Each year, a person’s telomeres are shortened by an average of 70 Base Pairs per year, but if you live a lifestyle that negatively affects your health, your telomeres can be shortened by 200-300 Base Pairs Basic of the year.
However, every time a cell divides Chromosomes also divide with telomere shortening. As a result, the rebuilding process of the body deteriorates. increased risk of various diseases When telomeres are shortened Cells cannot divide. it will decline, however, the telomerase enzyme can extend telomere length When telomeres lengthen, it slows down aging.
In 2009, the Nobel Prize in medicine was awarded to three American scientists, Elizabeth H. Blackburn, Carol W. Greider, and Jack W. Szostak, in medicine for the discovery of telomere protection. not to be destroyed by the telomere structure at the end of the chromosome and the enzyme telomerase (Telomerase) which helps repair telomeres to normal. It is considered an important body of anti-aging knowledge.
Prof Preeya Assoc explains that telomeres are naturally shortened as cells divide. which would mean ageing, senility and the chance of various degenerative diseases In addition, inappropriate behavior plays an important role in premature telomere shortening. including eating a lot of sugar, smoking a lot, drinking a lot of alcohol don’t exercise Sleep less regularly and be stressed all the time. In which obese people shorten telomeres faster than normal weight people. So obese people have many complications like diabetes, high blood pressure. high blood fat, etc.
“Telomer is a measure of our future health. If the short telomeres are slowed down or it can be made longer This means that it will help the cells to deteriorate less,” said Professor Preeya, Assoc.
However, if the telomeres are long, it will slow down aging, reduce wrinkles, look younger. Reduce the incidence of degenerative diseases sleep better But if the telomeres are short It will age prematurely, there will be wrinkles, wrinkled skin. causing a disease of degeneration and difficult to sleep
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