A team of researchers in Korea has made a significant discovery regarding the role of enzymes produced by intestinal microbes in maintaining human immune homeostasis. Led by Dr. Kim Myung-hee from the Microbiome Convergence Research Center at the Korea Bioscience and Biotechnology Research Institute, the team published their findings in the esteemed international journal ‘Cell Host & Microbe (IF 31.316)’.
The researchers found that an intestinal microorganism called Akkermansia mucinophila secretes a protein synthesizing enzyme known as ‘AmTARS (Akkermansia mucinophila threonyl-tRNA synthetase)’, which possesses anti-inflammatory immune regulatory properties. This enzyme is able to restore balance and harmony within the immune system by increasing the expression level of ‘anti-inflammatory cytokines’, which are essential factors in immune regulation. Additionally, the team discovered that AmTARS plays a role in healing damaged colon tissue, providing further evidence of its disease-relieving capabilities.
Impressively, the research team suggests that in the future, the ‘AmTARS’ enzyme could potentially be utilized in the development of treatments for inflammatory refractory immune diseases like inflammatory bowel disease. Dr. Kim Myung-hee, the lead researcher, explained, “The results of this analysis clearly demonstrate the interdependent relationship between the human body and the microorganisms (microbiome) that inhabit it.”
This groundbreaking study sheds light on the intricate connection between intestinal microbes and human immune health, offering hope for the development of novel therapeutic approaches to tackle immune-related disorders.
A research team in Korea has identified that enzymes produced by intestinal microbes maintain human immune homeostasis.
The research team led by Dr. Kim Myung-hee from the Microbiome Convergence Research Center at the Korea Bioscience and Biotechnology Research Institute said the content was published in the online edition of the international journal ‘Cell Host & Microbe (IF 31.316)’ on the 2nd.
Akkermansia mucinophila, an intestinal microorganism, secretes ‘AmTARS (Akkermansia mucinophila threonyl-tRNA synthetase)’, a protein synthesizing enzyme with anti-inflammatory immune regulatory function. It was analyzed that it restores homeostasis by increasing the expression level of ‘anti-inflammatory cytokine’, a factor.
AmTARS, a protein synthesizing enzyme, has also been confirmed to have a disease-relieving function by restoring damaged colon tissue.
Accordingly, the research team explained that the ‘AmTARS’ enzyme could be used in the future to develop treatments for inflammatory refractory immune diseases such as inflammatory bowel disease.
Dr said. Kim Myung-hee, who conducted the research, “The results of this analysis are an example that clearly shows how the human body and the microorganisms (microbiome) that live in the human body live in a mutually dependent relationship.”
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