Regulation of cellular energy metabolism (NAMPT) has been confirmed to be associated with the worsening of colon cancer
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A team led by Professor Yoo-seon Kim (Research Professor Seon-mi Hong and Graduate School student A-yeon Lee) from the Department of Biochemistry at Ajou University School of Medicine confirmed that regulation of NAMPT gene activity , which is involved in the process of energy metabolism of cells, can be used to determine the progression, prognosis and treatment direction of inflammatory colon cancer. It was announced on the 22nd that this has been done.
Inflammatory colon cancer is colon cancer caused by chronic inflammation and is known to have a lower survival rate than general colon cancer. The pathogenesis has been hypothesized to be that damage to the intestinal tissue caused by repeated inflammation and the microenvironment surrounding the cancer promote the progression of colon cancer during the remodeling process for recovery.
The research team found that the activity of the NAMPT gene plays a role in the conversion of macrophages, which are immune cells, into “tumor macrophages (M2-type tumor macrophages)” that promote the process of cancer progression, thus inducing a immunosuppressive microenvironment and promoting colon cancer A new exacerbation mechanism has been revealed.
In particular, it was confirmed that the expression of NAMPT and the expression levels of NAMPT-related genes in these tumor macrophages provide accurate information to predict the survival or response to treatment of colorectal cancer patients.
As a result, the research team said it can expect to develop an effective cancer immunotherapy for colon cancer targeting NAMPT.
NAD (nicotinamide adenine dinucleotide) is an essential metabolite involved in energy production, regulation of the redox reaction and signal transmission in all living cells. NAMPT is a key enzyme that maintains the amount of NAD in cells. NAMPT dysfunction has been reported to be related to various diseases such as diabetes, cancer, arthritis, and aging.
Professor Kim Yu-seon said: “This study is significant as it confirms the possibility of developing a new cancer immunotherapy that can predict the progression and prognosis of colorectal cancer and target the complex cancer microenvironment through regulatory pathway of NAMPT activity”.
This study, conducted with the support of the Mid-Career Researcher Support Project and the Basic Laboratory Support Project of the National Research Foundation of Korea and the Research Center of the Korea Institute for Health Industry Development, was published in the latest online edition of the international journal Advanced Science (IF 15.1) entitled “NAMPT-Driven M2 Polarization of Tumor-Associated Macrophages Leads” and was published with the title “To an Immunosuppressive Microenvironment in Colorectal Cancer (NAMPT-mediated tumor M2 type macrophage polarization-activate immunosuppressive microenvironment in colorectal cancer) )’.
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