▲ Dr Zheng Shaobin said that the simultaneous use of immunosuppressants and the oral antiviral drug Paxlovid will have an interaction. (Photo by reporter Ou Sumei)
Correspondent Ou Sumei / Taichung reports
He Nan, 46 years old, received a liver transplant and recovered well after surgery. Unexpectedly, he was recently diagnosed with Wuhan pneumonia (new coronavirus disease, COVID-19). After taking antiviral drugs, he developed a severe headache and other symptoms . , sought medical treatment in time Serious complications occurred.
Zheng Shaobin, director of Taichung Tzu Chi Hospital Organ Transplant Center, reminded patients that the interaction of anti-rejection drugs taken by organ transplant patients with antiviral drugs for new coronary pneumonia could be life-threatening. Blood levels and clinical status are very close. track.
Please read on…
Nan took immunosuppressive drugs (anti-rejection drugs) regularly after the transplant operation. At the end of September, she was quickly screened and diagnosed with Wuhan pneumonia. After taking the oral antiviral drug Paxlovid prescribed by the clinic doctor for 5 days, he had continuous headache, tossing and turning, and loss of appetite Wait for the symptoms, he endured the pain until the home isolation period ended, and then he went to the Liver Transplant Clinic of Taichung Tzu Chi Hospital for medical treatment. the concentration of his immunosuppressive drug was more than 10 times the upper limit of the normal value!
Antiviral + immunosuppressant almost fatal
Zheng Shaobin said that commonly used immunosuppressants and the oral antiviral drug Paxlovid have the same metabolic enzymes in the human body, Taking them at the same time will reduce the metabolism of immunosuppressants and increase the plasma concentration of immunosuppressants. Concentrations can excessive drugs cause kidney damage function and blood pressure neurological symptoms such as erection, insomnia, headache, tremors and paresthesia, and even secondary infections, serious drug side effects can be fatal and should not be ignored.
Zheng Shaobin noted that during the 5-day course of oral antiviral drugs for patients after organ transplantation, it is recommended to temporarily stop immunosuppressive drugs. After the 7th day, the plasma drug concentration should be measured, and then the time to resume should be reassessed the drug and dose, and the organ should be reminded Post-transplant patients infected with the disease must take the initiative to contact the doctor of the original transplant team to consult the anti-rejection modification that drug-related and tracking concentrations and clinical conditions during the antiviral drug course.
Currently, about 6.9 million people in Taiwan have been diagnosed with Wuhan pneumonia. The Ministry of Health and Welfare also reminded that the oral antiviral drug Paxlovid interacts with a variety of drugs. In addition to the 10 categories of drugs that are contra-approved, there are also 35 categories of drugs that need to be closely monitored.
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