A Superdodger in the study was a person with a key mutation on the gene that produces CCR5, resulting in no expression on white blood cells. HIV only binds to CD4 but does not help it to attach to the cells . This is a very important body of information. This led to people trying to come up with the idea of modifying the human gene to suppress CCR5 expression as a treatment for infection. or AIDS patients That used to be very popular news in the industry.
But Superdodger’sCovid-19 It is more difficult than in the case of HIV because we know that the virus uses the ACE2 receptor protein to enter cells. It would be very difficult for someone to have a mutation, as is the case with HIV, because ACE2 has many important functions. Specifically, it controls the body’s blood pressure system. Simply put, we lack ACE2 on cells so we cannot lack CCR5 on the cell surface. So the true definition of a COVID Superdodger would be: people who have never been infected Probably not, but probably someone who is infected and has never had more symptoms.
