Rama Hospital Genome Center Introduces New Strategy for COVID-19: Omicron GK and HK Variants Evade Immunity and Enhance Cell Surface Adhesion
August 14, 2023 – The medical genome center at the Faculty of Medicine Hospital (Hospital) Ramathibodi Mahidol University, recently unveiled their latest breakthrough in combating the COVID-19 pandemic. Through their official Facebook page, the Center for Medical Genomics announced the development of a new strategy to tackle the virus.
Scientists at the center have discovered a new variant called Omicron GK and HK, which possesses unique characteristics that allow it to evade current immunity solutions and demonstrate stronger adhesion to the cell surface compared to previous variants such as XBB and Eris “EG.5”. This enhanced adhesion is achieved through a flip combo mutation.
This mutation, referred to as the flip combo mutation, represents an evolutionary tactic employed by the virus survival mechanism. It enables the newly identified Omicron strain to counter natural immunity acquired through vaccination or previous infection. Furthermore, the flip combo mutation enhances the virus’ ability to bind more tightly to the cell surface by affecting specific amino acids, namely phenylalanine (F) and leucine (L).
In this mutation, the first site undergoes a polar flip from leucine (L) to phenylalanine (F), followed by a subsequent flip from phenylalanine (F) back to leucine (L). The combination of these two changes enables the viral spike to effectively evade immunity while increasing its binding capacity to the ACE2 receptor on the cell surface. As a result, the virus can penetrate cells more efficiently. This phenomenon is now known as the flip combo mutation, which has given rise to two novel XBB variants.
In other related news, the origin of GK or XBB.1.5.70 can be traced back to XBB.1.15, with mutations occurring on the adjacent backbones at L455F and F456L. Similarly, HK.3 or XBB.1.9.2.5.1.1.3 is derived from EG.5.1, featuring mutations on the adjacent backbones at L455F and F456L as well.
Currently, the Omicron variant containing the polar flip mutation has been detected in Brazil and Spain, but not yet in Thailand. These strains are expected to replace the original XBB strain and EG.5.1 in the near future.
Additionally, as COVID-19 continues to mutate, the relentless pursuit of the virus has prompted the US Food and Drug Administration to recommend the use of single-strain vaccines by late 2023 or early 2024. These vaccines, known as “Mono Valent,” specifically target XBB omikron substrains such as XBB.1.5, XBB.1.16, or XBB.2.3, which represent the most significant forward mutations of the virus.
It is important to note that the original strains, including Wuhan, Alpha, Beta, Gamma, Delta, Omicron-BA.1, BA.2, BA.4, and BA.5, have not been included in current vaccine formulations, as there is no scientific evidence suggesting a resurgence of the previous Omicron XBB strain.
These groundbreaking findings from the Rama Hospital Genome Center signify a crucial step forward in understanding and combatting the ever-evolving nature of the COVID-19 virus. As further research and development continue, these discoveries will play a vital role in shaping effective strategies to mitigate the impact of the pandemic.
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The mutation of COVID-19 has prompted the US Food and Drug Administration to endorse the use of single-strain vaccines in late 2023 or early 2024. These vaccines, termed “Mono Valent,” focus solely on the XBB omikron substrains XBB.1.5, XBB.1.16, or XBB.2.3, given their significant contributions to the ongoing mutation process of COVID-19.
The inclusion of original strains such as Wuhan, Alpha, Beta, Gamma, Delta, Omicron-BA.1, BA.2, BA.4, and BA.5 in the vaccine has been avoided due to the lack of scientific evidence supporting the re-emergence of the previous Omicron XBB strain.
In conclusion, the unveiling of the new Omicron GK and HK variants, along with their unique abilities to evade immunity and adhere more tightly to the cell surface, marks an important development in the fight against COVID-19. These findings provide valuable insights into the ever-evolving strategies employed by the virus and set the stage for innovative approaches to combat the ongoing pandemic.
Rama Hospital Genome Center unveils the latest “COVID-19” strategy, a new strain of Omicron GK and HK to evade immunity and adhere to the cell surface more tightly than XBB and Eris “EG. 5” with a flip combo mutation
Rama Hospital Genome Center unveils the latest “COVID-19” strategy, a new strain of Omicron GK and HK to evade immunity and adhere to the cell surface more tightly than XBB and Eris “EG. 5” with a flip combo mutation
on August 14, 2023 medical genome center Faculty of Medicine Hospital (Hospital)Ramathibodi Mahidol University Revealed through the Center for Medical Genomics Facebook page, he said
A flip combo mutation
The latest tactics of Omicron The new strain GK and HK are for immune evasion and stronger adhesion to the cell surface, which is better than XBB and Eris “EG.5” through flip combo mutation.
Scientists have discovered “Covid 19” A new strategy (New Trick) is an evolution for survival. Natural immunity from vaccination and infection can be avoided. better adhesion to the cell surface, calledFlip or Flip” In other words, there are two adjacent location mutations. A double/bipolar combo mutation, L455F and F456L, causes changes at the amino acid level.Phenylalanine (F)” and”leucine (L)“
The first mutant site flipped a pole from L to F and the subsequent pole flipped from F to L. Combining the two changes allows the viral spike to evade immunity and bind to the cell surface (ACE2) more tightly, allowing ‘the virus penetrates cells better This phenomenon has been called Flip combo mutation has given birth to two new XBB variants.
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1. GK or XBB.1.5.70 originates from XBB.1.15, mutating on two adjacent backbones, L455F and F456L, and
2. HK.3 or XBB.1.9.2.5.1.1.3 Derived from EG.5.1, there are mutations on two adjacent backbones, L455F and F456L.
Omicron containing was found A polar flip mutation (Flip combined mutation) “Brazil” meet “Spain” Not yet found in Thailand Both strains are expected to replace the original XBB strain as well as EG.5.1 in the near future.
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from the mutation ofCOVID 19 The relentless push forward led the US Food and Drug Administration to say in June 2023 that vaccination in late 2023-early 2024 should use a single-strain vaccine, or “Mono Valent” Only targeting XBB omikron substrans XBB.1.5, XBB.1.16 or XBB.2.3 is at least current on the forward mutation of COVID-19.
Without adding the original strains like Wuhan, Alpha, Beta, Gamma, Delta, Omicron-BA.1,BA.2,BA.4,BA.5. It was added to the vaccine because there was no scientific evidence to suggest that the previous Omicron XBB strain would re-emerge.
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