Restless Legs Syndrome Affects Both Sexes
- FRANKFURT – Restless Legs Syndrome (RLS), characterized by an irresistible urge to move the legs, substantially impacts quality of life.
- The German Brain Foundation described RLS in a February 2025 press release as an impulse triggered by unpleasant sensations in the legs, frequently enough described as painful, pulling,...
- RLS can affect individuals of any age or gender; however, pregnant women are disproportionately affected.
Restless legs syndrome: Pregnancy Increases Long-Term Risk
Table of Contents
- Restless legs syndrome: Pregnancy Increases Long-Term Risk
- Restless Legs Syndrome (RLS) and Pregnancy: Your Questions Answered
- What is Restless Legs Syndrome (RLS)?
- What are the main symptoms of RLS?
- How common is RLS?
- How does pregnancy affect RLS?
- Is there an increased risk of chronic RLS after pregnancy?
- Why is early management of RLS crucial during pregnancy?
- What factors can contribute to RLS?
- Are there preventative measures for RLS?
- What are the serious consequences of untreated RLS?
- How is RLS treated?
- can genetics play a role in RLS?
- What are the other risk factors for RLS?
- Summary of key Findings
FRANKFURT – Restless Legs Syndrome (RLS), characterized by an irresistible urge to move the legs, substantially impacts quality of life. German brain research indicates that pregnancy can exacerbate the condition and increase the likelihood of its recurrence later in life.
The German Brain Foundation described RLS in a February 2025 press release as an impulse triggered by unpleasant sensations in the legs, frequently enough described as painful, pulling, throbbing, or electric-like. These sensations typically occur while lying down and can severely disrupt sleep and daily life.
Pregnancy and RLS: A Heightened Risk
RLS can affect individuals of any age or gender; however, pregnant women are disproportionately affected. Studies suggest that up to one-third of pregnant women experiance RLS,wiht symptoms sometimes severe enough to warrant drug therapy. While symptoms often subside after pregnancy, research indicates a significantly higher risk of the condition returning later in life for those who experienced it during pregnancy.

Increased Risk of Permanent RLS After Pregnancy
According to German brain research, women who experience RLS during pregnancy face a fourfold increased risk of developing chronic RLS later in life. Early management of RLS symptoms is crucial to minimize potential pregnancy complications. Sleep deprivation resulting from RLS has been linked to premature births, cesarean sections, gestational diabetes, and high blood pressure during pregnancy.
Factors Contributing to RLS
Several factors can increase the likelihood of developing RLS:
- Certain antidepressants (serotonin reuptake inhibitors)
- Sedentary lifestyle
- Prolonged sitting
- Iron deficiency
- Alcohol consumption (potential link)
- Smoking (potential link)
- Caffeine intake (potential link)
- Certain medications (potential link)
Prof. Dr. Frank Erbguth, President of the German Brain Foundation, emphasizes the importance of awareness regarding these risks, stating that preventative measures can be taken. Modifying risk factors such as antidepressant use (where possible), increasing physical activity to combat a sedentary lifestyle, and addressing iron deficiencies through diet are recommended.
Serious Consequences of Untreated RLS
While avoiding alcohol, cigarettes, and excessive caffeine is generally advised during pregnancy, RLS can still develop. Medication is frequently enough prescribed for treatment, including for pregnant women when necessary.In severe cases, alternative medications are available to manage RLS effectively.
The MSD Manual notes that genetics can play a role in RLS, with over a third of primary RLS patients reporting a family history of the condition. Other risk factors identified by the MSD Manual include iron deficiency anemia, uremia, neuropathy, pregnancy, ParkinsonS disease, multiple sclerosis, and spinal cord disorders.
Restless Legs Syndrome (RLS) and Pregnancy: Your Questions Answered
What is Restless Legs Syndrome (RLS)?
Restless Legs Syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the legs. This urge is often accompanied by uncomfortable sensations in the legs, such as painful, pulling, throbbing, or electric-like feelings.These sensations typically occur when lying down and can severely disrupt sleep and daily life. According to the German Brain Foundation, it is considered a compulsive disorder.
What are the main symptoms of RLS?
The primary symptom of RLS is the overwhelming urge to move your legs. Other common symptoms of RLS include:
- Unpleasant sensations in the legs (described as painful, pulling, throbbing, or electric-like)
- Symptoms that worsen during periods of inactivity (sitting or lying down)
- Relief of symptoms by moving the legs
- Symptoms that are worse in the evening or at night
- Disrupted sleep
How common is RLS?
RLS affects individuals of any age or gender.According to the provided data,up to one-third of pregnant women experience it. RLS can considerably effect quality of life.
How does pregnancy affect RLS?
Research indicates that pregnancy can exacerbate RLS and increase the likelihood of its recurrence later in life. Up to one-third of pregnant women experience RLS, with symptoms sometimes severe enough to warrant drug therapy. While symptoms often subside after pregnancy,there’s a higher risk of the condition returning.
Is there an increased risk of chronic RLS after pregnancy?
Yes, according to German brain research, women who experience RLS during pregnancy face a fourfold increased risk of developing chronic RLS later in life.
Why is early management of RLS crucial during pregnancy?
Early management of RLS symptoms is crucial to minimize potential pregnancy complications. Sleep deprivation resulting from RLS has been linked to:
- Premature births
- Cesarean sections
- Gestational diabetes
- High blood pressure during pregnancy
What factors can contribute to RLS?
Several factors can increase the likelihood of developing RLS. These include:
- Certain antidepressants (serotonin reuptake inhibitors)
- Sedentary lifestyle
- Prolonged sitting
- Iron deficiency
- Alcohol consumption (potential link)
- Smoking (potential link)
- Caffeine intake (potential link)
- Certain medications (potential link)
Are there preventative measures for RLS?
Yes, according to Prof. Dr. frank Erbguth, President of the German Brain Foundation, modifying risk factors can help. Recommended preventative measures include:
- modifying antidepressant use (if possible)
- increasing physical activity
- Addressing iron deficiencies through diet
What are the serious consequences of untreated RLS?
Untreated RLS can lead to several serious consequences, especially during pregnancy. RLS-related sleep deprivation can contribute to pregnancy complications like premature births, and also affect overall health.
How is RLS treated?
Medication is frequently prescribed for treatment. Alternative medications are available in severe cases. while avoiding alcohol, cigarettes, and excessive caffeine is generally advised during pregnancy, medication can still be necessary.
can genetics play a role in RLS?
Yes, the MSD Manual notes that genetics can play a role in RLS. Over a third of primary RLS patients report a family history of the condition.
What are the other risk factors for RLS?
Other risk factors identified by the MSD Manual include:
- Iron deficiency anemia
- Uremia
- Neuropathy
- Pregnancy
- Parkinson’s disease
- Multiple sclerosis
- Spinal cord disorders
Summary of key Findings
Here’s a concise summary of essential information regarding RLS and pregnancy:
| Aspect | Details |
|---|---|
| Definition | Irresistible urge to move legs; uncomfortable sensations. |
| Pregnancy Impact | exacerbates RLS; increases recurrence risk. Up to one-third of pregnant women experience it. |
| Increased Risk | Women with RLS during pregnancy have a fourfold increase risk of chronic RLS later in life. |
| Consequences of Untreated RLS during Pregnancy | Potential complications include premature birth, gestational diabetes, Cesarean sections. |
| Factors | Antidepressants, sedentary lifestyle, iron deficiency, alcohol, smoking, caffeine, genetics, etc. |
