Revolutionary VR System for Mice Advances Brain Research
Mice Get a Virtual Reality Upgrade: New System Revolutionizes Brain Research
Budapest, Hungary – A groundbreaking virtual reality (VR) system designed specifically for mice is poised to revolutionize brain research and pave the way for innovative vision restoration therapies. Developed by the BrainVisionCenter Research Institute and Competence Center (BVC) in collaboration with the HUN-REN institute of experimental Medicine (HUN-REN KOKI), the system, named Moculus, offers an unprecedented level of realism, allowing scientists to study brain function and learning processes with unparalleled accuracy.
The research, led by a team of scientists including Linda Judák, gergely Szalay, Gergely Dobos, and Balázs Rózsa, was published in the prestigious journal Nature Methods on December 12th. The project aligns with the BVC’s core mission, founded by Botond Roska and Balázs Rózsa, to develop therapies for vision restoration and treatments for central nervous system disorders.
“Mice perceive the world in three dimensions only when the virtual reality is specifically tailored to their vision,” explains Gergely Szalay, lead researcher at HUN-REN KOKI and BVC. “Accurate representation of their visual surroundings is essential for meaningful results.”
Unlike previous VR systems that relied on two-dimensional projections, Moculus utilizes a sophisticated setup, including a custom-designed treadmill, dual screens, and an optical system providing an ultra-wide field of view exceeding 180 degrees. This immersive experience allows mice to interact naturally with their virtual surroundings, while researchers map brain activity using two-photon microscopy.
The results are remarkable. “Rodents’ visual learning abilities are surprisingly advanced,” reveals linda Judák, another leading researcher on the project. “In contrast to earlier VR systems, where learning could take 5–9 days, mice can now acquire new visual information within a single day or even as quickly as 30 minutes.”
This rapid learning capability, coupled with the ability to observe corresponding brain activity at the cellular level, marks a significant step forward in understanding neural mechanisms governing learning and decision-making processes.
Balázs Rózsa, BVC director and group leader at HUN-REN KOKI and Pázmány Péter University, emphasizes the system’s potential for therapeutic advancements. “Moculus generates precise spatial-temporal brain activity patterns that encode visual elements of the environment more accurately than ever before,” he says.”This enables the development of advanced 3D vision-restoration tools that can activate neurons with unprecedented precision, offering a new level of artificial vision accuracy.”
The Moculus system represents a major milestone in the BVC’s long-term mission to restore vision and develop specialized research tools. As Rózsa highlights,”When we founded the BrainVisionCenter in late 2021,we prioritized vision restoration and developing the tools necessary for cortical vision therapies. Moculus is a crucial step in this journey, allowing gene-based techniques to be tested more effectively than ever.”
with no similar tools currently available on the market, Moculus is poised to attract significant interest in the field of neuroscience research. by providing unparalleled accuracy in replicating the visual experience for rodents, the technology offers an essential platform for both basic scientific discovery and applied therapeutic advancements.
A Mouse’s-Eye View: new VR System Revolutionizes Brain Research
Budapest, Hungary – Imagine peering through the eyes of a mouse experiencing a fully immersive virtual world. This is the reality made possible by Moculus, a groundbreaking virtual reality (VR) system designed specifically for mice, developed by the BrainVisionCenter Research Institute and Competence Center (BVC) alongside the HUN-REN Institute of Experimental Medicine (HUN-REN KOKI). This innovative technology is poised to revolutionize brain research and pave the way for groundbreaking vision restoration therapies.
Published in the prestigious journal Nature Methods on December 12th, the research, led by a team of scientists including Linda Judák, Gergely Szalay, Gergely dobos, and Balázs Rózsa, highlights the system’s remarkable capabilities. Unlike previous VR systems that relied on two-dimensional projections, Moculus employs a highly sophisticated setup. The system includes a custom-designed treadmill, dual screens, and an optical system that creates an ultra-wide field of view exceeding 180 degrees, allowing mice to interact naturally with their virtual environment. Researchers can then map brain activity using two-photon microscopy.
“Mice perceive the world in three dimensions only when the virtual reality is specifically tailored to their vision,” explains Gergely Szalay, lead researcher at HUN-REN KOKI and the BVC. “Accurate representation of their visual surroundings is essential for meaningful results.”
The results are astonishing. “Rodents’ visual learning abilities are surprisingly advanced,” reveals Linda Judák, another leading researcher on the project. “In contrast to earlier VR systems, where learning coudl take 5–9 days, mice can now acquire new visual information within a single day or even as quickly as 30 minutes.”
This rapid learning, coupled with the ability to observe corresponding brain activity at the cellular level, marks a significant leap forward in understanding neural mechanisms governing learning and decision-making processes.
“Moculus generates precise spatial-temporal brain activity patterns that encode visual elements of the environment more accurately than ever before,” says Balázs Rózsa, BVC director and group leader at HUN-REN KOKI and Pázmány Péter University. This precision, he emphasizes, will enable the development of advanced 3D vision-restoration tools capable of activating neurons with unprecedented accuracy, potentially leading to a new level of artificial vision.
Moculus represents a major milestone for the BVC’s long-term mission to restore vision and develop specialized research tools. As Rózsa notes, “When we founded the BrainVisionCenter in late 2021, we prioritized vision restoration and developing the tools necessary for cortical vision therapies.Moculus is a crucial step in this journey, allowing gene-based techniques to be tested more effectively than ever.” With no similar tools currently available, Moculus is poised to attract significant interest within the neuroscience community, offering an essential platform for both basic scientific discovery and targeted therapeutic advancements.
