Sebum Metabolism & Skin Inflammation in Psoriasis: New Link Discovered
- For decades, psoriasis has been primarily understood as an immune-mediated disease.
- Psoriasis affects an estimated 7.5 million adults in the United States, and approximately 80% of those affected experience mild to moderate symptoms, while 20% have moderate to severe...
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New Research Links Psoriasis to Lipid Metabolism, Offering Potential for Targeted Therapies
Published December 12, 2023, Updated December 12, 2025 05:24:48
Psoriasis: Beyond an Immune Disorder
For decades, psoriasis has been primarily understood as an immune-mediated disease. However, new research from the Medical University of Vienna challenges this conventional wisdom, demonstrating a crucial link between the condition and disruptions in how skin cells process lipids (fats). Professor Irvine Wagner,leading the research team,stated on December 12,2023,”Our results confirm that psoriasis is not only an immune disorder,but is also closely linked to a defect in lipid metabolism within skin cells.” Al nahdan News reported on the discovery.
Psoriasis affects an estimated 7.5 million adults in the United States, and approximately 80% of those affected experience mild to moderate symptoms, while 20% have moderate to severe disease. The National Psoriasis Foundation provides detailed information on disease severity.
The Role of FABP5: A Potential Biomarker
The research identified FABP5 (Fatty Acid Binding protein 5) as a key player in this lipid metabolism dysfunction. Kazuhiko Matsuoka, a researcher involved in the study, highlighted the potential of FABP5, stating on December 12, 2023, ”FABP5 may in the future become a biomarker that helps develop targeted therapies, especially for patients who do not respond well to conventional immunotherapies.”