Serum Uric Acid and Cardiovascular Risk in Older Adults
- Okay, here's a breakdown of the references cited in the provided text, organized for clarity:
- Affect of aging on serum uric acid levels: longitudinal changes in a large Japanese population group.
- References Supporting Sensitivity Analyses/Time-Dependent Confounding:
Okay, here’s a breakdown of the references cited in the provided text, organized for clarity:
References Supporting Stratification:
* [2] Kuzuya M, Ando F, Iguchi A, Shimokata H. Affect of aging on serum uric acid levels: longitudinal changes in a large Japanese population group. J Gerontol Biol sci Med Sci.2002;57(10):M660-4. (Supports stratification by age)
* [3] Zitt E, Fischer A, lhotta K, Concin H, Nagel G. Sex- and age-specific variations,temporal trends and metabolic determinants of serum uric acid concentrations in a large population-based Austrian cohort. Sci Rep. 2020;10(1):7578. (Supports stratification by age and sex)
* [4] Conen D, Wietlisbach V, Bovet P, et al. Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country. BMC Public Health. 2004;4:9. (Supports stratification by age)
* [13] Harrold LR, Yood RA, Mikuls TR, et al. Sex differences in gout epidemiology: evaluation and treatment. Ann Rheum Dis. 2006;65(10):1368-72. (Supports stratification by sex)
References Supporting Sensitivity Analyses/Time-Dependent Confounding:
* [1] Johnson RJ, Bakris GL, Borghi C, et al.Hyperuricemia, acute and chronic kidney disease, hypertension, and cardiovascular disease: report of a scientific workshop organized by the National Kidney Foundation. Am J Kidney Dis. 2018;71(6):851-65. (Discusses eGFR and ACR as potential mediators)
* [14] Schisterman EF, Cole SR, Platt RW. Overadjustm (The citation is incomplete, but it relates to overadjustment and mediation)
Other References:
* [12] (Appears to be a general reference, likely to a study population or data source, but the full citation is not provided in the excerpt.)
Key Takeaways from the Text Regarding References:
* The authors stratified their analysis by age, sex, and SUA levels. they provide references to justify each of these stratification choices.
* They performed sensitivity analyses to address potential time-dependent confounding, and they cite references to explain why certain covariates (eGFR, ACR) might be mediators rather then confounders.
* The references are used to support the methodological choices and provide context for the study.